Overview
Phenolsulfonphthalein (PSP), also known as Phenol Red, is a synthetic pH indicator widely used in medical and laboratory settings. It was first introduced in the early 20th century for renal function testing due to its ability to change color based on pH levels. As a dye, PSP transitions from yellow (pH 6.8 or below) to red (pH 8.2 or above), making it ideal for monitoring acid-base reactions. Its stability and distinct color shift have cemented its role in clinical diagnostics and chemical research.
Physical and Chemical Properties
Phenolsulfonphthalein is a red crystalline powder with a molecular weight of 354.38 g/mol. It decomposes around 300°C and exhibits notable solubility in water, alcohol, and alkaline solutions. The compound’s key feature is its pH-dependent color change, which occurs due to structural alterations in acidic or alkaline environments. This reversible reaction is highly reproducible, ensuring reliability in both medical and industrial applications.
Main Applications
PSP is primarily used in renal function tests, where its excretion rate helps assess kidney efficiency. It is injected intravenously, and its clearance from the bloodstream is measured over time. In laboratories, PSP serves as a visual pH indicator for titrations and culture media. It is also employed in cell biology to monitor metabolic activity, particularly in detecting acid production during bacterial growth.
Safety and Storage
While PSP is not highly toxic, proper handling is essential to avoid irritation. Use gloves and goggles when handling the powder, and ensure adequate ventilation to prevent inhalation. Store the compound in a tightly sealed container away from light and moisture. Prolonged exposure to air or humidity can degrade its efficacy, so desiccants are recommended for long-term storage.
B2B Procurement Guide
When sourcing PSP, prioritize suppliers who provide certificates of analysis (CoA) to verify purity (typically 95–99%). Bulk purchases (1 kg or more) often qualify for discounts, but confirm lead times for large orders. Consider logistical factors such as temperature-controlled shipping if ordering during extreme weather. Reputable suppliers should also offer technical support for application-specific queries.
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