Peptide Hydrogel
Overview
Peptide hydrogel is a class of soft materials formed by the self-assembly of short peptide sequences under physiological conditions. These hydrogels mimic natural extracellular matrices, making them ideal for biomedical applications. The gelation process is often triggered by changes in pH, temperature, or ionic strength. The material's modular design allows customization of mechanical properties, degradation rates, and bioactive motifs. This adaptability has led to its adoption in research labs and clinical trials, particularly for regenerative medicine and controlled drug release systems.
Physical and Chemical Properties
Peptide hydrogels exhibit viscoelastic behavior with storage moduli typically ranging from 0.1-20 kPa, adjustable by peptide concentration or crosslinking. They maintain >90% water content while retaining structural integrity, resembling natural tissues' hydration levels. The peptides' amino acid sequence determines secondary structures (β-sheets, α-helices) that drive self-assembly. Most formulations are stable at physiological pH (7.4) but may dissolve under extreme acidic/basic conditions. Degradation occurs via proteolytic enzymes or hydrolysis over days to months.
Main Applications
In drug delivery, peptide hydrogels provide sustained release of therapeutics like growth factors or anticancer drugs, with release kinetics controlled by mesh size and degradation. Their injectability enables minimally invasive administration. Tissue engineering utilizes these gels as 3D scaffolds for stem cell differentiation and organoid growth. Specific peptide motifs (e.g., RGD) enhance cell adhesion. Emerging uses include diabetic wound healing dressings and neural regeneration matrices due to their axon-guiding nanofibrous structures.
Safety and Storage
Pre-formed hydrogels are generally sterile-filterable or autoclavable, while peptide powders require aseptic handling. Long-term storage at 4°C preserves stability; freeze-thaw cycles should be avoided to prevent fibril disruption. Although inherently biocompatible, endotoxin levels must be <0.25 EU/mL for implantable applications. In vitro cytotoxicity testing (ISO 10993-5) is recommended for new formulations. Users should wear PPE when handling dry peptides to prevent respiratory irritation.
B2B Procurement Guide
Industrial buyers should verify: 1) cGMP compliance for clinical-grade material, 2) batch-to-batch consistency in rheological properties, and 3) supplier capabilities for custom sequence design. Bulk orders (100g+) may qualify for 15-30% discounts. Key specifications include gelation time (minutes to hours), minimum gelation concentration (typically 0.1-2% w/v), and endotoxin certification. Consider suppliers offering technical support for formulation optimization and sterilization validation.
Related Manufacturers
- 主营：抗病毒肽、胸腺曲南、定制合成、多肽合、标签多肽、磷酸化多肽、自组装多肽、多肽合成、酶荧光底物、免疫缺损病毒、钙蛋白酶抑制剂、荧光修饰、环肽、长肽合成、短肽、双环肽
- 主营：水凝胶、特殊peg
- 主营：活性脂、三苯胺、mof材料、蛋白和多肽水凝胶定制、聚乙二醇、海藻酸钠、聚苯乙烯、蛋白交联剂、琥珀酰亚胺酯、月桂酸甘油酯、二元醛基cof单体
- 主营：甲氧基聚乙二醇、氨基聚乙二醇、羧基聚乙二醇、肽支架水凝胶、巯基聚乙二醇、羟基聚乙二醇、马来酰亚胺聚乙二醇、四臂聚乙二醇、荧光素聚乙二醇、叠氮聚乙二醇、硅烷聚乙二醇、炔基聚乙二醇、生物素聚乙二醇、丙烯酸酯聚乙二醇、活性脂聚乙二醇、Boc保护基团聚乙二醇、Fmoc保护基团聚乙二醇、生物素小分子PEG衍生物、甲氧基小分子PEG衍生物
- 主营：嵌段共聚物、合成磷脂、荧光染料、壳聚糖水凝胶、PEG、点击化学、量子点
- 主营：腐植酸钠、腐植酸、铁粉、水凝胶、磁铁粉、钕铁硼磁粉
- 主营：高吸水保水剂、高分子吸水树脂、阴离子聚丙烯酰胺、水凝胶、聚丙烯酰胺絮凝剂、国标聚丙烯酰胺、高纯度聚丙烯酰胺、PAM聚丙烯酰胺、水处理聚丙烯酰胺、净水聚丙烯酰胺、絮凝剂、沉降药剂、高分子药剂、农用保水剂、园林保水剂、土壤保水剂、农林保水剂、抗旱保水剂、农业土壤保水剂、抗旱专用保水剂、吸水材料、非离子聚丙烯酰胺、阳离子聚丙烯酰胺、絮凝药剂、水处理药剂
- 主营：石墨、膨胀石墨、导电石墨粉、水凝胶、防静电墨粉、阻燃石墨粉、鳞片石墨粉、超细石墨粉、云母、云母片、茶色云母片、云母粉、电气石、电气石粉、电气石颗粒、天然云母片、透明云母片、导热石墨、绝缘云母片、耐高温云母、云母板、岩片、贝壳片、膨润土、钙基膨润土、纳基膨润土
- 主营：导光凝胶、穴位贴、晕车贴、漱口水凝胶定制、止痒凝露、痛经贴、碘伏棉签、酒精棉签、鼻腔润滑剂、疝气贴、穴位贴敷治疗贴、远红外理疗贴、热敷贴、三伏贴、磁疗贴巴布贴、酒精棉球、碘伏棉球、酒精棉片、小儿贴、退热凝胶、冰凉贴、退热贴、膏贴
- 主营：膏药空贴、膏药布、Pu膜胶贴、水凝胶、透气胶带、酒精 消毒液、造口袋
- 主营：羧甲基纤维素钠银敷料、疝修补片、鱼骨缝合线、水凝胶、疝修补补片、强生止血夹、强生止血纱、磷酸锆钠银藻酸盐敷料、含银敷料、美必康、透析导管、长期透析导管、进口透析导管、巴德透析导管、组织胶水、百克钳、美皮康、保赫曼、经鼻喂养管、植入式给药装置、强生超声刀、血栓抽吸导管
- 主营：黄原胶、大豆分离蛋白、瓜尔胶、水凝胶、果胶、海藻酸钠、结冷胶、卡拉胶、抗性糊精、可得然胶、明胶、魔芋粉、琼脂、羧甲基纤维素钠、阿斯巴甜、安赛蜜、赤藓糖醇、低聚半乳糖、低聚果糖、低聚木糖、低聚异麦芽糖、核糖、木糖、阿拉伯糖、菊粉、麦芽糖醇
- 主营：农林保水剂、吸水树脂、聚丙烯酸钠、水凝胶、聚丙烯酰胺、抑尘剂、制香胶粉、彩色吸水树脂、边坡绿化保水剂、边坡绿化粘合剂、羟丙基甲基纤维素、羟丙基瓜尔胶、腻子粉润滑剂、絮凝剂
- 主营：甘氨酸、水苏糖、除涩剂、水凝胶、红曲黄、儿茶素、米糠素、甘露醇、硫酸锰、他拉胶、一水物、酪蛋白、磷酸氢、鱼油粉、牛磺酸、褪黑素、碳酸镁、赖氨酸、纤维素、刹口剂、卡拉胶、泡多源、柚苷酶、乳糖酶、脯氨酸、筋力源
- 主营：硬脂酸镁、药用聚乙二醇、泊洛沙姆188、水凝胶、泊洛沙姆407、聚乙二醇—15羟基硬脂酸酯、巴斯夫进口蓖麻油聚烃氧酯EL35、巴斯夫聚氧乙烯氢化蓖麻油RH40、巴斯夫进口Soluplus、微晶纤维素、聚维酮k30、聚维酮k90、羧甲淀粉钠、低取代羟丙纤维素、羟丙纤维素、羟丙甲纤维素、乳糖、麦芽糊精、交联聚维酮、交联羧甲纤维素钠、海藻糖、甘羟铝、聚丙烯酸钠、卡波姆、亚什兰进口羟乙基纤维素
- 主营：牌甘油、碳酸镁、牌饲料、水凝胶、牌乳酸、叶绿素、蚯蚓肽、壳聚糖、牌磷脂、脑磷脂、牌脱氢、甲壳素、牌琼胶、牌果酸、牌肌酸、牌羟丙、氧化镁、精氨酸、牌酵母、牌果胶、牌糊精、大米肽、牌糖精、氨酸钠、牌菊粉、藻油粉
- 主营：硫酸钡、碳酸钙、硅溶胶、水凝胶、苄基胂酸、甲基磺酸、氨基磺酸、正硅酸乙酯、多聚甲醛