Overview
Pentafluoro(4-aminophenyl)sulfur is an organofluorine compound featuring a pentafluorinated sulfur group attached to an aminophenyl ring. It serves as a versatile building block in synthetic chemistry, particularly for introducing fluorine atoms into complex molecules. The compound’s unique electronic properties, imparted by the fluorine atoms, make it valuable in designing bioactive molecules with enhanced stability or metabolic resistance. While not widely commercialized, it is typically synthesized in specialized laboratories for targeted applications. Its use is prevalent in research settings focusing on fluorinated pharmaceuticals or crop protection agents, where fluorine incorporation can alter biological activity.
Physical and Chemical Properties
The compound exhibits moderate solubility in polar organic solvents but is generally insoluble in water. Its crystalline form suggests stability under standard conditions, though it may degrade upon prolonged exposure to humidity or UV light. The presence of both an amino group and pentafluorosulfur moiety creates reactivity toward electrophiles and nucleophiles, enabling diverse derivatization pathways. Thermal analysis data is limited, but analogous compounds decompose at temperatures above 150°C. Handling requires caution due to potential dust formation, which could pose inhalation hazards. Analytical characterization typically involves NMR (19F and 1H) and mass spectrometry to confirm purity and structure.
Main Applications
Primary applications include its role as an intermediate in synthesizing fluorinated active pharmaceutical ingredients (APIs), such as antiviral or anticancer agents. The electron-withdrawing nature of the pentafluorosulfur group can enhance drug binding affinity or modulate pharmacokinetics. In agrochemicals, it may contribute to the development of herbicides or fungicides with improved environmental persistence. Niche uses extend to materials science, where it could serve as a precursor for fluorinated polymers or coatings with specialized surface properties. However, these applications remain exploratory due to the compound’s high cost and limited commercial availability.
Safety and Storage
As a fine chemical, it requires handling in well-ventilated areas with appropriate personal protective equipment (PPE), including gloves and safety goggles. Although toxicity data is scarce, structural analogs suggest potential irritancy to skin, eyes, and respiratory systems. Spills should be contained with inert absorbents and disposed of as hazardous waste. Storage recommendations include airtight containers under inert gas (e.g., nitrogen) to prevent moisture absorption or oxidative degradation. Shelf life is typically 12–24 months when stored at 2–8°C, though suppliers should provide batch-specific stability information.
B2B Procurement Guide
Procurement challenges include limited supplier options and potential lead times for custom synthesis. Buyers should prioritize vendors with ISO-certified facilities and documented quality control processes, especially for GMP-grade material. Technical specifications must detail purity (typically ≥95% by HPLC), residual solvent levels, and isotopic labeling if applicable. Pricing is project-dependent, with small-scale research quantities (1–10g) ranging from $200–$500/g, while bulk orders may negotiate lower rates. Contracts should address regulatory compliance (e.g., REACH, TSCA) and supply chain transparency, particularly for pharmaceutical end-uses.
Related Manufacturers
- 主营：乙酸镁、并噻吩、三蝶烯、硫酸锂、硫酸锶、氟苯基、二乙烯、肌氨酸、嘧菌酯、碳酸镁、新癸酸、赖氨酸、多佐胺、咯菌腈、乙氧基、茚三酮、咖啡酸、α-氟萘、羟乙基、异恶唑、2223-82-7、喹啉黄、庚二酸、虫酰肼、吡咯并
- 主营：溴苯腈、乙基己酸锌、荧光增白剂、24、羟乙基纤维素、乙酰乙酸乙酯
- 主营：l谷氨酸、d谷氨酸、l亮氨酸、人白三烯c4、人补体7、人补体1q、largininehcl、人钙调素、人雌三醇、人唾液酸、人多巴胺、人强啡肽、bocl丙氨酸、l异亮氨酸、猪d二聚体、d天冬氨酸、l天冬氨酸、猪白介素12、pcdh1试剂盒、elisa试剂盒、dl半胱氨酸、人磷脂酶a2、dl谷氨酰胺、人降钙素原、人轮状病毒