Overview
(-)-β-Peltatin is a lignan compound primarily extracted from Podophyllum peltatum (mayapple) and related species. It is structurally related to podophyllotoxin, a well-known precursor for semisynthetic anticancer drugs like etoposide. The compound exhibits significant biological activity, particularly in disrupting microtubule formation, making it valuable for pharmaceutical research. Historically, (-)-β-Peltatin has been studied for its potential role in traditional medicine, where Podophyllum extracts were used for their cytotoxic properties. Modern applications focus on its use as an intermediate in synthesizing more potent derivatives for oncology treatments.
Physical and Chemical Properties
(-)-β-Peltatin is a crystalline solid with a molecular weight of 688.63 g/mol. Its solubility profile favors organic solvents like methanol and dimethyl sulfoxide (DMSO), while it has limited solubility in water. The compound is sensitive to light and heat, requiring controlled storage conditions to maintain stability. Key chemical features include a glucoside moiety attached to the peltatin backbone, which influences its bioavailability and metabolic pathways. Analytical methods such as HPLC and NMR are commonly used to verify purity and structural integrity, with commercial grades typically exceeding 95% purity.
Main Applications
The primary use of (-)-β-Peltatin is in pharmaceutical research, particularly as a precursor for anticancer drug development. Its mechanism of action involves inhibiting microtubule polymerization, which disrupts cell division in rapidly proliferating cells. This property has spurred interest in derivatives for treating cancers like lung and testicular carcinomas. Beyond oncology, the compound is explored for antiviral and anti-inflammatory applications. However, its adoption in commercial drugs remains limited due to the need for structural optimization to enhance efficacy and reduce toxicity.
Safety and Storage
(-)-β-Peltatin requires careful handling due to its cytotoxic nature. Direct contact with skin or eyes may cause irritation, necessitating the use of gloves, goggles, and lab coats. Work should be conducted in a fume hood to minimize inhalation risks. For long-term storage, the compound should be kept in airtight containers under refrigeration (2-8°C) and protected from light. Stability studies suggest it degrades under prolonged exposure to high temperatures or humidity, so suppliers often provide desiccants with shipments.
B2B Procurement Guide
When sourcing (-)-β-Peltatin, prioritize suppliers with demonstrated expertise in phytochemical extraction and purification. Request certificates of analysis (COA) detailing purity (ideally >98%), residual solvents, and heavy metal content. GMP or ISO-certified manufacturers are preferred for consistency. Pricing varies significantly based on quantity and purity, with bulk purchases (10+ grams) often discounted. Lead times can be lengthy due to the specialized extraction process, so plan procurement well in advance of research timelines. Consider secondary suppliers to mitigate supply chain risks.
Related Manufacturers
- 主营：盾叶鬼臼素、对照品、标准品
- 主营：异常山乙素、酒渣碱、芦丁标准品、对照品标准品
- 主营：花姜酮、氨基辛酸、葡萄糖苷、芍药素、飞燕草素、天竺葵素、矮牵牛素、天竺葵色素、氯化锦葵色素、半乳糖苷、阿拉伯糖苷、去氢钩藤碱