Overview
Pacritinib is a small molecule inhibitor targeting JAK2 and FLT3 kinases, developed for the treatment of myelofibrosis and other hematologic disorders. It is known for its selective action, minimizing off-target effects compared to broader kinase inhibitors. Clinical studies have demonstrated its efficacy in reducing spleen volume and improving symptoms in myelofibrosis patients, particularly those with thrombocytopenia. Pacritinib is administered orally, offering convenience over injectable alternatives.
Physical and Chemical Properties
Pacritinib is a white to off-white crystalline powder with a molecular weight of 479.58 g/mol. Its molecular formula is C28H29N7O, indicating a complex organic structure optimized for kinase inhibition. The compound is soluble in dimethyl sulfoxide (DMSO) and slightly soluble in water, which influences its formulation for oral administration. Stability studies recommend storage at -20°C in airtight containers to prevent degradation.
Main Applications
Pacritinib is primarily used in the treatment of myelofibrosis, a rare bone marrow disorder characterized by abnormal blood cell production and fibrosis. It is particularly beneficial for patients with low platelet counts (thrombocytopenia), who may not tolerate other JAK inhibitors. Ongoing research explores its potential in acute myeloid leukemia (AML) and other FLT3-driven malignancies. Its dual inhibition of JAK2 and FLT3 makes it a versatile candidate for combination therapies in hematologic cancers.
Safety and Storage
Pacritinib should be handled in accordance with laboratory safety protocols, including the use of gloves and protective eyewear. Inhalation or ingestion must be avoided due to potential pharmacological effects. For long-term storage, the compound should be kept at -20°C in a dry, dark environment to maintain stability. Bulk quantities require controlled conditions to prevent moisture absorption or thermal degradation.
B2B Procurement Guide
When procuring Pacritinib, B2B buyers should prioritize suppliers with certified Good Manufacturing Practice (GMP) compliance. Key specifications include purity (≥98%) and the absence of residual solvents. Due to its high cost, buyers may negotiate bulk discounts or explore contractual agreements for regular supply. Regulatory documentation, such as Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS), should accompany all shipments.
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