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p-Methoxymethyl

Updated: 2026-08-03

Overview

p-Methoxymethyl, also known as 4-Methoxymethylbenzene, is an organic compound primarily used as an intermediate in the synthesis of pharmaceuticals and fragrances. Its molecular structure includes a methoxy group attached to a methyl-substituted benzene ring, making it a versatile building block in organic chemistry. This compound is typically available as a colorless to pale yellow liquid with a mild aromatic odor. Its stability and reactivity profile make it suitable for various chemical reactions, particularly in the production of more complex molecules.

Physical and Chemical Properties

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p-Methoxymethyl exhibits a density of approximately 1.02 g/cm³ and a boiling point in the range of 200-205°C. It is soluble in common organic solvents such as ethanol, ether, and acetone, but has limited solubility in water. The compound is relatively stable under normal conditions but can react with strong oxidizing agents, necessitating careful handling. Its molecular weight of 138.16 g/mol and the presence of both methoxy and methyl groups contribute to its reactivity in substitution and addition reactions.

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Main Applications

The primary use of p-Methoxymethyl is as an intermediate in the pharmaceutical industry, where it serves as a precursor for various active pharmaceutical ingredients (APIs). It is also employed in the synthesis of fragrances and flavors due to its aromatic properties. Additionally, this compound finds applications in organic synthesis, particularly in the preparation of more complex molecules. Its versatility makes it a valuable tool for chemists working on drug discovery and material science.

Safety and Storage

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p-Methoxymethyl should be handled with care to avoid inhalation, skin contact, or ingestion. Proper personal protective equipment (PPE), including gloves and goggles, is recommended when working with this chemical. Storage conditions should include a cool, dry place away from direct sunlight and oxidizing agents. Containers should be tightly sealed to prevent evaporation and contamination. In case of spillage, absorb with inert material and dispose of according to local regulations.

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B2B Procurement Guide

When procuring p-Methoxymethyl, it is essential to verify the purity and quality of the product. Reputable suppliers should provide a Material Safety Data Sheet (MSDS) and certificates of analysis (CoA). Prices can vary significantly based on quantity and supplier, so it is advisable to request quotes from multiple sources. Bulk purchases may offer cost advantages, but storage capacity and shelf life should be considered. Always ensure compliance with local regulations regarding the transportation and handling of chemicals.

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