Overview
p-Hydroxybutyrophenone is an organic compound belonging to the aromatic ketone family. It serves as a versatile intermediate in specialty chemical manufacturing, particularly valued in the fragrance industry for its sweet, floral-woody odor profile. The compound is synthesized through Friedel-Crafts acylation of phenol with butyryl chloride. As a B2B chemical, it is typically supplied in 25kg fiber drums or custom packaging for industrial users. Its commercial significance stems from its dual functionality as both a fragrance component and a building block for more complex molecules in pharmaceutical synthesis.
Physical and Chemical Properties
The compound crystallizes as white needles or powder with a characteristic sweet odor reminiscent of raspberry and carnation. It demonstrates moderate stability under normal conditions but may undergo photochemical reactions when exposed to UV light. Chemically, it exhibits typical ketone reactivity including susceptibility to nucleophilic addition and reduction to secondary alcohols. The phenolic hydroxyl group enables etherification and esterification reactions, making it valuable for producing derivatives with modified solubility and volatility properties.
Main Applications
In perfumery, p-hydroxybutyrophenone serves as a fixative and middle note in floral compositions, particularly for carnation and lilac accords. It's frequently used in soap, detergent, and cosmetic fragrances due to its stability in alkaline media. The pharmaceutical industry employs it as an intermediate for synthesizing β-blockers and other active pharmaceutical ingredients. Emerging applications include its use as a photoinitiator in UV-curable inks and coatings, where its absorption characteristics are advantageous.
Safety and Storage
As an industrial chemical, proper handling requires nitrile or neoprene gloves, safety goggles, and adequate ventilation. The material safety data sheet (MSDS) classifies it as an irritant to skin and mucous membranes. Storage recommendations include keeping containers tightly closed in a cool (below 30°C), dry place segregated from strong oxidizers. Bulk storage areas should have secondary containment to prevent environmental contamination in case of spills. Shelf life typically exceeds two years when stored properly.
B2B Procurement Guide
Industrial buyers should specify technical grade (98% min purity) for fragrance applications or pharmaceutical grade (99.5%+) for medicinal use. Key procurement considerations include batch-to-batch consistency in odor profile and color. Reliable suppliers should provide certificates of analysis including gas chromatography purity data, residual solvent levels, and heavy metal content. For international shipments, verify compliance with regional regulations (REACH, TSCA, etc.). MOQs typically range from 100kg to ton quantities, with price breaks at metric ton volumes.
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