Overview
p-Hexylacetophenone is an aromatic ketone with a molecular formula of C14H20O. It is commonly used as a key intermediate in the synthesis of fragrances and pharmaceuticals due to its floral odor and stable chemical structure. The compound is synthesized through Friedel-Crafts acylation of hexylbenzene with acetic anhydride or acetyl chloride. Industrial production typically involves strict quality control to ensure high purity (≥98%) for downstream applications.
Physical and Chemical Properties
p-Hexylacetophenone is a colorless to pale yellow liquid with a density of approximately 0.92-0.94 g/cm³. It is soluble in common organic solvents like ethanol and ether but insoluble in water, making it suitable for non-aqueous formulations. Its boiling point ranges between 280-290°C, and it exhibits moderate volatility. The compound's aromatic ketone structure contributes to its reactivity in condensation and reduction reactions, which are exploited in organic synthesis.
Main Applications
The primary use of p-hexylacetophenone is in the fragrance industry, where it serves as a building block for floral and woody scent compounds. It is also employed in pharmaceutical intermediates, particularly for synthesizing active ingredients with aromatic moieties. In research, it acts as a precursor for liquid crystal materials and specialty polymers. Its stability and predictable reactivity make it a versatile reagent in fine chemical production.
Safety and Storage
p-Hexylacetophenone is classified as a flammable liquid and should be stored in tightly sealed containers away from heat and open flames. Proper ventilation is essential to avoid vapor accumulation. Personal protective equipment (PPE), including nitrile gloves and chemical goggles, is recommended during handling. In case of skin contact, wash immediately with soap and water. Dispose of waste according to local regulations for ketone compounds.
B2B Procurement Guide
When procuring p-hexylacetophenone, prioritize suppliers with certifications like ISO 9001 or GMP compliance. Specify purity requirements (e.g., ≥98%) and request a Certificate of Analysis (CoA) for batch verification. Bulk purchases (e.g., drum quantities) often reduce unit costs. Consider logistics: the compound is typically shipped in HDPE or glass containers with hazardous material labeling. Evaluate supplier lead times and stability of supply chains for long-term contracts.
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