Overview
4-Butylacetophenone is an aromatic ketone derived from acetophenone, featuring a butyl group at the para position. It is primarily used in specialty chemical applications due to its distinct floral odor and reactivity as an intermediate. The compound is synthesized through Friedel-Crafts acylation or other organic reactions, with commercial grades typically offering 95-99% purity. In industrial contexts, it serves as a versatile building block for fragrances, agrochemicals, and pharmaceuticals. Its molecular structure allows for further functionalization, making it valuable for custom synthesis. B2B buyers often source it in bulk quantities (drums or totes) from fine chemical suppliers.
Physical and Chemical Properties
As a liquid at room temperature, 4-butylacetophenone exhibits moderate volatility with a boiling point around 270°C. Its density is slightly lower than water (~0.97 g/cm³), and it is miscible with most organic solvents but immiscible with aqueous solutions. The compound’s stability under neutral conditions makes it suitable for long-term storage when properly sealed. Key chemical properties include its reactivity as a ketone, participating in reactions like reductions (to alcohols) or condensations. The aromatic ring also enables electrophilic substitutions. Analytical methods for quality control include GC-MS and HPLC to verify purity and detect impurities such as unreacted precursors.
Main Applications
The fragrance industry utilizes 4-butylacetophenone as a mid-note in perfumery, contributing to floral and woody accords. Its stability in cosmetic formulations (e.g., soaps, lotions) makes it a preferred choice over more volatile alternatives. In pharmaceuticals, it acts as an intermediate for synthesizing anti-inflammatory or antimicrobial compounds. Research applications include its use as a ligand or precursor in catalytic processes. Lesser-known uses include specialty coatings and polymer additives, where its aromaticity enhances material properties.
Safety and Storage
Handle 4-butylacetophenone with standard lab precautions: use fume hoods to avoid vapor inhalation and wear nitrile gloves to prevent skin contact. Although not highly toxic, prolonged exposure may cause irritation. Spills should be contained with absorbent materials (e.g., vermiculite) and disposed of as hazardous waste. Store in stainless steel or HDPE containers under inert gas (nitrogen) to prevent oxidation. Shelf life typically exceeds two years when kept away from moisture and extreme temperatures. Transport regulations classify it as non-hazardous for most shipping methods, but verify local guidelines.
B2B Procurement Guide
When procuring 4-butylacetophenone, prioritize suppliers with ISO 9001 certification and batch-specific Certificates of Analysis (CoA). Key specifications to confirm include purity (≥98%), water content (<0.5%), and residual solvent levels. Custom synthesis options are available for derivatives like deuterated or halogenated versions. Bulk pricing tiers usually start at 25 kg, with discounts for metric ton quantities. Logistics considerations include shipping temperature (ambient) and packaging compatibility (avoid PVC for long-term storage). For international purchases, ensure compliance with REACH, TSCA, or other regional regulations.
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