Overview
Berberrubine, also known as Oxoberberine, is a bioactive alkaloid derived from berberine, a compound found in plants like Berberis vulgaris and Coptis chinensis. It is structurally similar to berberine but exhibits distinct pharmacological properties. Historically, berberrubine has been used in traditional Chinese medicine for its potential therapeutic effects. In modern research, berberrubine has gained attention for its antioxidant and anti-inflammatory properties. Studies suggest it may also have antimicrobial and anticancer potential, though further clinical validation is required. Its role in pharmaceutical development continues to be explored.
Physical and Chemical Properties
Berberrubine appears as a yellow to orange crystalline powder with a melting point around 200-205°C. It is soluble in organic solvents like ethanol, methanol, and DMSO but has limited solubility in water. The compound's molecular weight is 323.34 g/mol, and its molecular formula is C19H17NO4. Key chemical properties include its ability to act as an antioxidant and its potential to modulate inflammatory pathways. These characteristics make it a subject of interest in pharmacological research, particularly in studying oxidative stress-related conditions.
Main Applications
Berberrubine is primarily used in pharmaceutical research and traditional medicine. Its potential anti-inflammatory and antimicrobial properties make it a candidate for developing new therapeutic agents. It is also studied for its role in managing metabolic disorders and oxidative stress. In addition to its medicinal uses, berberrubine is sometimes included in dietary supplements aimed at supporting immune health. However, its efficacy in these applications requires further scientific validation. The compound is also used as a reference standard in analytical chemistry for quality control of herbal extracts.
Safety and Storage
Berberrubine should be stored in a cool, dry place, protected from light and moisture to maintain stability. Proper handling is essential to avoid inhalation or skin contact, as its safety profile in humans is not fully established. Laboratory personnel should use appropriate personal protective equipment (PPE), including gloves and goggles, when working with berberrubine. Disposal should comply with local regulations for chemical waste. Always refer to the material safety data sheet (MSDS) for detailed safety instructions.
B2B Procurement Guide
When procuring berberrubine, prioritize suppliers with verified certifications (e.g., ISO, GMP) to ensure product quality. Request certificates of analysis (CoA) to confirm purity, typically assessed via HPLC or TLC. Batch-to-batch consistency is critical for research applications. Pricing varies based on purity and quantity, with higher purity grades commanding premium prices. Consider negotiating bulk purchase discounts for large-scale research needs. Ensure the supplier provides proper documentation for customs clearance if importing internationally.
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