Overview
Oxane, commonly referred to as 1,4-dioxane, is a heterocyclic organic compound that appears as a colorless liquid with a faint ether-like odor. It is highly miscible with water and most organic solvents, making it a versatile solvent in various industrial processes. Oxane is primarily produced as a byproduct in the manufacture of ethylene glycol and is widely used in pharmaceuticals, cosmetics, and chemical synthesis. Due to its stability and solvent properties, oxane is often employed as a stabilizer for chlorinated solvents and as a reaction medium in organic chemistry. However, its potential health risks, including carcinogenicity, have led to regulatory scrutiny and the development of safer alternatives in some applications.
Physical and Chemical Properties
Oxane has a molecular weight of 88.11 g/mol and a density of 1.033 g/cm³. It melts at 11.8 °C and boils at 101.1 °C, making it a relatively volatile liquid at room temperature. The compound is highly soluble in water and most organic solvents, which contributes to its widespread use as a solvent. Chemically, oxane is stable under normal conditions but can form explosive peroxides when exposed to air and light over time. It is also flammable, with a flash point of 12 °C, requiring careful handling and storage. Its ether-like structure provides excellent solvation properties, particularly for polar and non-polar compounds.
Main Applications
Oxane is predominantly used as a solvent in the pharmaceutical industry for the synthesis of drugs and intermediates. Its ability to dissolve a wide range of substances makes it valuable in the production of cosmetics, where it acts as a carrier for fragrances and other active ingredients. In the chemical industry, oxane serves as a stabilizer for chlorinated solvents like 1,1,1-trichloroethane, preventing their degradation. It is also utilized in laboratory settings as a reaction medium for organic synthesis. Despite its utility, regulatory concerns have prompted some industries to seek alternatives, particularly in consumer products.
Safety and Storage
Oxane is classified as a flammable liquid and a suspected carcinogen, necessitating strict safety measures during handling and storage. It should be stored in a cool, dry, well-ventilated area away from heat sources and open flames. Containers must be tightly sealed to prevent evaporation and the formation of explosive peroxides. Personal protective equipment (PPE), including gloves and goggles, is recommended when working with oxane. In case of spills, absorbent materials should be used, and contaminated areas must be thoroughly ventilated. Proper disposal methods should be followed to minimize environmental impact.
B2B Procurement Guide
When procuring oxane, businesses should prioritize suppliers who provide detailed material safety data sheets (MSDS) and certificates of analysis (CoA) to ensure product quality and compliance with safety regulations. Purity levels, typically ranging from 99% to 99.9%, should be verified based on intended use. Bulk purchases may offer cost advantages, but storage capabilities must be assessed to handle large quantities safely. Packaging options include drums and intermediate bulk containers (IBCs), with considerations for compatibility and leak prevention. Long-term contracts with reliable suppliers can ensure consistent supply and favorable pricing.
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