Overview
Ortho-Phthalaldehyde (OPA) is an aromatic dialdehyde with the formula C8H6O2. It is widely recognized for its role as a high-level disinfectant, particularly in healthcare settings where it is used to sterilize medical instruments. OPA offers advantages over traditional disinfectants like glutaraldehyde, including faster action and lower toxicity under normal use conditions. OPA was introduced as a disinfectant in the 1990s and has since gained popularity due to its efficacy against a broad spectrum of microorganisms, including mycobacteria and spores. It is commonly supplied as a liquid solution, often at concentrations of 0.5% to 1% for practical use.
Physical and Chemical Properties
OPA is a pale yellow to colorless liquid at room temperature, with a characteristic aromatic odor. It has a molecular weight of 134.13 g/mol and a density of 1.19 g/cm³. The compound melts at 56-58°C and boils at 266°C, demonstrating stability under typical storage conditions. OPA is soluble in water and most organic solvents, which facilitates its use in aqueous disinfectant solutions. Its high reactivity with primary amines makes it effective for cross-linking proteins, a property exploited in both disinfection and biochemical applications. However, this reactivity also necessitates careful handling to avoid unwanted reactions.
Main Applications
The primary use of OPA is as a high-level disinfectant for medical and dental instruments, particularly endoscopes and other heat-sensitive devices. It is effective against bacteria (including antibiotic-resistant strains), viruses, and fungal spores, with a typical contact time of 5-12 minutes. Beyond disinfection, OPA serves as a reagent in biochemical research, where it is used to label proteins and detect primary amines. It is also a precursor in the synthesis of certain polymers and dyes. In industrial settings, OPA’s reactivity is leveraged for cross-linking and stabilizing materials.
Safety and Storage
OPA is classified as an irritant to skin, eyes, and respiratory systems. Proper personal protective equipment (PPE), including gloves and goggles, is essential when handling the compound. Adequate ventilation or fume hoods should be used to minimize inhalation exposure. Storage recommendations include keeping OPA in a cool, dry place away from light and oxidizing agents. Containers should be tightly sealed to prevent moisture absorption and degradation. Spills should be neutralized with a reducing agent like sodium bisulfite and cleaned up promptly.
B2B Procurement Guide
When procuring OPA, B2B buyers should prioritize suppliers that provide detailed certificates of analysis (CoA) specifying purity (typically ≥98%) and confirming the absence of heavy metals or other contaminants. Compliance with regional regulations (e.g., EPA, EU biocidal products) is critical for disinfectant applications. Prices vary based on volume and purity, with bulk purchases (e.g., 25-liter drums) often offering cost savings. Buyers should also inquire about packaging options (e.g., amber bottles to protect against light degradation) and lead times, as OPA may require special handling during transportation.
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