Overview
Orexin B, also known as Hypocretin-2, is a neuropeptide that is part of the orexin family, which includes Orexin A and Orexin B. It is produced in the hypothalamus and plays a significant role in regulating appetite, sleep-wake cycles, and energy homeostasis. Orexin B is derived from the same precursor protein as Orexin A and binds to the OX2 receptor, which is one of the two G-protein-coupled receptors for orexins. Research has shown that Orexin B is involved in various physiological processes, including feeding behavior, arousal, and neuroendocrine regulation. Its role in sleep disorders, such as narcolepsy, has been extensively studied, making it a potential target for therapeutic interventions. The peptide is commonly used in neurological research to understand its mechanisms and potential applications in treating metabolic and sleep-related conditions.
Physical and Chemical Properties
Orexin B is a peptide with the molecular formula C152H252N50O44S and a molecular weight of approximately 3568.0 g/mol. It appears as a white to off-white lyophilized powder and is soluble in water, with slight solubility in organic solvents. The peptide is stable under recommended storage conditions, which typically involve keeping it at -20°C in a dry, dark place. The peptide's structure includes multiple amino acid residues that contribute to its biological activity. Orexin B's solubility and stability make it suitable for various research applications, including in vitro and in vivo studies. Proper handling and storage are essential to maintain its integrity and ensure accurate experimental results.
Main Applications
Orexin B is primarily used in neurological research to study its role in regulating appetite, sleep-wake cycles, and energy homeostasis. Its involvement in sleep disorders, such as narcolepsy, has made it a focal point for therapeutic research. Potential applications include the development of drugs to treat sleep disorders, metabolic conditions, and other neurological disorders. In addition to its therapeutic potential, Orexin B is used in basic research to understand the mechanisms of orexin signaling and its effects on the central nervous system. Researchers also explore its role in reward pathways and addiction, providing insights into broader neurological and behavioral processes.
Safety and Storage
Orexin B should be handled with care, using appropriate personal protective equipment to avoid exposure. It is recommended to store the peptide at -20°C in a dry, dark place to maintain its stability and prevent degradation. Proper labeling and storage conditions are essential to ensure the peptide's longevity and effectiveness in research applications. Researchers should also be aware of the peptide's solubility and handling requirements to avoid contamination or loss of activity. Safety data sheets and supplier guidelines should be consulted for specific handling and storage instructions to ensure safe and effective use in laboratory settings.
B2B Procurement Guide
When procuring Orexin B for research purposes, it is essential to verify the supplier's reputation and the quality of the product. Key considerations include the peptide's purity, as indicated by the certificate of analysis, and the supplier's ability to provide consistent and reliable batches. Prices may vary depending on the purity and quantity required, so it is advisable to compare offerings from multiple suppliers. Additionally, researchers should ensure that the peptide is shipped under appropriate conditions to maintain its stability. Proper documentation, including material safety data sheets and handling instructions, should be provided by the supplier to facilitate safe and effective use in the laboratory.
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