Overview
OPSS-PEG-OPSS is a heterobifunctional PEG derivative designed for thiol-selective crosslinking in biomedical applications. Its symmetrical OPSS termini react with sulfhydryl groups (-SH) to form stable disulfide bonds, enabling controlled conjugation of peptides, proteins, or nanoparticles. The PEG spacer enhances solubility and reduces immunogenicity, making it ideal for therapeutic formulations. This compound is particularly valuable in antibody-drug conjugates (ADCs), where it links cytotoxic drugs to monoclonal antibodies. Its versatility extends to surface modifications, nanoparticle functionalization, and diagnostic assays, driven by its predictable reactivity and biocompatibility.
Physical and Chemical Properties
OPSS-PEG-OPSS exhibits water solubility due to its PEG backbone, with solubility varying slightly based on molecular weight (typically 500–20,000 Da). The disulfide bonds in OPSS groups are cleavable under reducing conditions, allowing controlled release of conjugated molecules. The compound is stable at neutral pH but degrades in strong acids or bases. Its thermal properties depend on PEG length, with shorter chains appearing as powders and longer chains as viscous liquids. The density (~1.1–1.2 g/cm³) and melting point (50–60°C) are consistent with PEG-based materials. Storage at -20°C under argon or nitrogen is recommended to prevent oxidation.
Main Applications
In bioconjugation, OPSS-PEG-OPSS bridges thiol-containing biomolecules (e.g., cysteine residues in antibodies) with other functional groups, enabling site-specific modifications. It is a cornerstone in ADC development, ensuring precise drug-to-antibody ratios and minimal aggregation. Nanotechnology applications include coating gold nanoparticles or quantum dots for targeted imaging. In drug delivery, it stabilizes liposomes or polymeric micelles. Research-grade uses span crosslinking hydrogels and biosensor fabrication, leveraging its reversible disulfide bonds for responsive systems.
Safety and Storage
OPSS-PEG-OPSS is non-toxic but requires handling with gloves and eye protection to avoid irritation. Powder forms may pose inhalation risks; use in fume hoods. The disulfide bonds can emit trace sulfur oxides upon decomposition, necessitating ventilation. For long-term stability, store lyophilized or in solution at -20°C, avoiding repeated freeze-thaw cycles. Solutions should be prepared in degassed buffers to prevent thiol oxidation. Suppliers typically provide technical datasheets with batch-specific safety data.
B2B Procurement Guide
Procure OPSS-PEG-OPSS from reputable suppliers specializing in PEG derivatives. Key specifications include PEG molecular weight (e.g., 2kDa, 5kDa), purity (≥95% by HPLC), and endotoxin levels (<0.1 EU/mg for injectables). Custom modifications (e.g., maleimide-PEG-OPSS) are available for specialized applications. Bulk pricing is negotiable for orders >10g, with lead times of 2–4 weeks. Request COA (Certificate of Analysis) and MSDS for compliance. For drug development, ensure the supplier follows cGMP standards and provides stability data.
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