Overview
Ononin, chemically known as (±)-Formononetin, is a naturally occurring isoflavone found in plants such as red clover (Trifolium pratense) and Astragalus species. It is a bioactive compound with potential health benefits, including antioxidant and estrogenic properties. Ononin is widely used in pharmaceutical research and nutraceutical formulations due to its potential therapeutic effects. In traditional medicine, plants containing Ononin have been used to support women's health and as general tonics. Modern research explores its role in hormone regulation, cardiovascular health, and anti-inflammatory applications. The compound is typically extracted and purified for laboratory and industrial use.
Physical and Chemical Properties
Ononin is an off-white to pale yellow crystalline powder with a molecular weight of 284.26 g/mol. It has a melting point of approximately 258-260°C and is soluble in organic solvents like methanol and ethanol, but only slightly soluble in water. The compound is stable under recommended storage conditions but may degrade when exposed to prolonged light or moisture. Its molecular structure includes a flavonoid backbone with methoxy and hydroxyl functional groups, contributing to its bioactivity. Ononin's solubility and stability profile make it suitable for formulation in capsules, tablets, and liquid extracts in nutraceutical products.
Main Applications
Ononin is primarily used in pharmaceutical and nutraceutical industries. It is studied for its potential estrogenic activity, which may support menopausal symptom relief and bone health. Research also investigates its antioxidant properties and potential role in reducing oxidative stress. In the dietary supplement market, Ononin is included in products targeting hormonal balance and women's health. Additionally, it serves as a reference standard in laboratory research to study isoflavone metabolism and bioavailability. Its applications extend to functional foods and cosmetic formulations, where bioactive plant compounds are valued for their health-promoting effects.
Safety and Storage
Ononin should be handled with care to avoid inhalation or skin contact. Personal protective equipment, such as gloves and goggles, is recommended when working with the compound. It is generally considered safe at typical usage levels, but excessive intake should be avoided due to limited long-term safety data. Proper storage involves keeping the compound in a cool, dry place, protected from light and moisture. Sealed containers with desiccants are ideal to maintain stability. Shelf life typically ranges from 2-3 years when stored correctly, but batch-specific stability data should be consulted for precise guidelines.
B2B Procurement Guide
When procuring Ononin for commercial or research purposes, buyers should prioritize suppliers with verified certifications (e.g., ISO, GMP). Key considerations include purity levels (typically 95%-98% by HPLC), batch-to-batch consistency, and documentation such as Certificates of Analysis (CoA). Pricing varies based on quantity and purity, with bulk purchases often offering cost advantages. Reliable suppliers provide transparent sourcing information, including plant origin and extraction methods. Buyers should also inquire about lead times, packaging options (e.g., aluminum bags, glass vials), and compliance with regional regulations for pharmaceutical or nutraceutical use.
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