Overview
Oncomodulin (OCM) is a small calcium-binding protein belonging to the parvalbumin family. Initially identified in tumor tissues, it has since been found in normal tissues including the inner ear and reproductive organs. The protein contains EF-hand motifs that enable calcium ion binding, playing roles in cellular calcium signaling and homeostasis. While its exact physiological functions remain under investigation, OCM has drawn significant research interest due to its overexpression in certain cancers. This characteristic makes it a potential biomarker and therapeutic target. The protein's small size and stability facilitate various laboratory applications.
Physical and Chemical Properties
Oncomodulin is a relatively small protein with a molecular weight of approximately 11-12 kilodaltons. Its structure includes two EF-hand calcium-binding domains, characteristic of proteins in this family. The protein demonstrates high thermal stability and maintains functionality across a range of pH conditions. The calcium-binding capacity of OCM is central to its biological activity, with dissociation constants in the micromolar range. This property allows it to participate in calcium buffering and signaling pathways. Analytical techniques such as mass spectrometry and circular dichroism are commonly used to characterize its physical properties.
Main Applications
In research settings, oncomodulin serves primarily as a tool for studying calcium signaling pathways and their dysregulation in disease states. Its association with certain tumors makes it valuable for cancer research, particularly in investigations of tumor microenvironment and metastatic processes. The protein also finds application in diagnostic development, where it may serve as a marker for specific cancer types. Emerging applications include its potential use in regenerative medicine, with studies exploring its role in nerve regeneration and other repair processes.
Safety and Storage
As with most laboratory reagents, standard precautions should be observed when handling oncomodulin. This includes wearing appropriate personal protective equipment and working in controlled environments. The protein is generally stable when stored properly at -20°C in lyophilized form. For long-term storage, maintaining desiccated conditions is recommended to preserve activity. Reconstituted solutions should typically be used promptly or stored at 4°C for short-term use. Always follow manufacturer recommendations for specific product formulations.
B2B Procurement Guide
When sourcing oncomodulin for research or commercial applications, several factors merit consideration. Purity levels (typically >95% for research applications) should be verified through certificates of analysis. The source (recombinant vs. native) may impact both price and suitability for specific applications. Batch-to-batch consistency is crucial for experimental reproducibility, making supplier reliability an important factor. Lead times can vary significantly depending on formulation and purity requirements. For large-scale purchases, establishing direct relationships with manufacturers may offer advantages in pricing and supply chain stability.
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