Overview
Oligomycin is a family of macrolide antibiotics produced by Streptomyces species, with Oligomycin A being the most studied variant. First isolated in the 1950s, it gained prominence as a specific inhibitor of mitochondrial ATP synthase (Complex V). Its ability to block oxidative phosphorylation makes it invaluable for studying cellular energy metabolism. In biochemical research, oligomycin serves as a critical tool compound for investigating mitochondrial dysfunction, cellular respiration, and metabolic pathways. The compound exhibits high specificity for the FO subunit of ATP synthase, making it a reference standard in bioenergetics studies.
Physical and Chemical Properties
Oligomycin A presents as a white crystalline solid with limited water solubility but good solubility in organic solvents like ethanol and DMSO. Its macrolide structure contains multiple chiral centers, contributing to its stereospecific binding to ATP synthase. The compound is stable when stored properly but may degrade under prolonged exposure to light or moisture. Spectroscopic analysis reveals characteristic absorption peaks useful for purity verification. The molecular weight (791.07 g/mol for Oligomycin A) and formula (C45H74O11) are critical for mass spectrometry applications. Researchers should note that different oligomycin variants (A, B, C) may exhibit slightly varying properties and potencies.
Main Applications
In research laboratories, oligomycin primarily serves to investigate mitochondrial function and cellular energy metabolism. It is routinely used to measure mitochondrial membrane potential and oxygen consumption rates in cell biology studies. Cancer researchers employ oligomycin to study the Warburg effect and tumor cell metabolism. The pharmaceutical industry utilizes oligomycin as a reference compound for developing new metabolic modulators. Additionally, it finds application in toxicology studies to model mitochondrial dysfunction and in agricultural research investigating fungal ATPases. Recent applications extend to neurodegenerative disease research, particularly in Parkinson's and Alzheimer's models.
Safety and Storage
Oligomycin requires careful handling due to its high toxicity (LD50 ~1-3 mg/kg in mice). Always use appropriate PPE including gloves, lab coat, and eye protection when working with the compound. Conduct procedures in a fume hood to prevent inhalation exposure. For long-term storage, maintain aliquots at -20°C in airtight, light-resistant containers under inert gas when possible. Avoid repeated freeze-thaw cycles. Dispose of waste according to local regulations for toxic organic compounds. First aid measures include rinsing exposed skin/eyes with water and seeking immediate medical attention for ingestion incidents.
B2B Procurement Guide
When sourcing oligomycin for research or industrial use, prioritize suppliers with certified analytical data (HPLC purity, mass spectrometry verification). Request batch-specific certificates of analysis including biological activity validation. Research-grade purity (≥95%) is standard for most applications. Consider ordering smaller quantities initially to verify performance in your specific application. For bulk purchases (gram quantities), negotiate pricing and confirm stability data for long-term storage. Reputable manufacturers typically offer oligomycin in various packaging options from milligram to gram quantities, with custom formulations available for specific research needs.
Related Manufacturers
- 主营：透析袋、移液器、SIGMA、寡霉素、赛默飞、爱思进、康宁、离心管、巴氏吸管、保存管、封板膜、细胞爬片、滤器、ELISA试剂盒
- 主营：透析袋、移液器、SIGMA、寡霉素、赛默飞、爱思进、吸头/枪头、离心管、巴氏吸管、保存管、封板膜、细胞爬片、滤器、ELISA试剂盒
- 主营：化学试剂、生物试剂、分析试剂、寡霉素、基准试剂、生化试剂
- 主营：化工原料、诺氟羧酸、精细化工产品、(r)-3-氨基丁醇、兰索拉唑氯化物、氯甲基氯磺酸酯
- 主营：碘海醇、葡甲胺、氨甲环酸、寡霉素A、盐酸柔红霉素、甘油磷酸钠、海藻糖、葡乙胺、古龙酸、托吡酯、潮霉素B、替卡西林钠克拉维酸钾、星孢菌素、盐酸阿霉素、碘帕醇
- 主营：双草酸酯、二茂铁甲醛
- 主营：1689-89-0、酒石酸、61438-64-0、9寡霉素、81810-66-4、17316-67-5、31430-15-6、68786-66-3、42461-84-7、115550-35-1、217500-96-4、101831-37-2、129496-10-2、沃尼妙林、丹诺沙星、非泼罗尼、加米霉素、能霉素钠、达氟沙星、奥苯达唑、粘杆菌素、双氢链霉素、酸泰妙菌素、盐酸四咪唑、盐酸沙拉沙星
- 主营：寡霉素A、白蜡树素、百两金素、半齿泽兰素
- 主营：莪术二酮、人参皂苷rc、自制对照品、寡霉素A、淫羊藿次苷
- 主营：寡霉素A、莪术二酮、人参皂苷rc
- 主营：对照品、科研实验、试剂盒、寡霉素C、多糖、安石榴苷、儿茶素、绿原酸、尿石素、人参皂苷、花青素、维生素、异鼠李素、甘草系列、人参系列、补骨脂系列、雷公藤系列、黄芩系列、柴胡系列、丹参系列、酸枣仁系列、重楼系列、大黄系列、五味子系列、化合物、黄芪皂苷系列
- 主营：蛋白酶、淀粉酶、果胶酶、胰酵素、崩溃酶、蜗牛酶、乳糖酶、肌酸激酶、葡球菌酶、绿色木霉、心肌黄酶、亮抑酶肽、纤维素酶、木聚糖酶、-glucosidase、亮抑肽酶、硫代辅酶、枯草杆菌、羧化辅酶、氯化酵素、脆壁质酶、细胞溶解酶、乙醇脱氢酶、透明质酸酶、氯化溶菌酶
- 主营：17746-77-9、625392-06-5、三癸基铝、寡霉素、1423716-55-5、1547041-34-8、甲氧苯基、磺胺曲沙唑、8-二羟基萘、三十二烷基铝、甲氧基苯甲酸、4-氯嘧啶盐酸盐
- 主营：萘苯胺、甘氨酸、甘氨酰、萘酚绿、硫酸锌、二苯胍、羟钴胺、磷酸铵、牛磺酸、褪黑素、肉桂醇、中性红、碳酸镁、肉桂醛、视黄醛、丙炔酸、alliinase、茜素红、肠激酶、达比加、脯氨酸、异丁苯、辛基酚、碘乙烷、叶绿素
- 主营：木质醛、酮锌吡、褪黑素、甘油酯、粘蛋白、薄荷脑、苯氨基、苹果酸、三羟基、皮粉五、甲基蓝、生根粉、动力精、薄荷酮、二羟基、3α羟基、萘酰胺、胶粘剂、磷酸三、嗪二酮、氨酸钾、嘧啶酮、氨酸镁、407环氧、酸cas号