Octa-Arm PEG
Overview
Octa-Arm PEG is a star-shaped derivative of polyethylene glycol (PEG) featuring eight hydroxyl-terminated arms radiating from a central core. Its unique architecture provides enhanced functionality for crosslinking and conjugation compared to linear PEG. The compound is synthesized via controlled polymerization, ensuring uniform arm length and reactivity. Widely adopted in biomedical fields, Octa-Arm PEG serves as a versatile scaffold for constructing hydrogels, drug carriers, and biocompatible coatings. Its multi-arm structure enables high-density functionalization, making it ideal for applications requiring controlled release or 3D matrix formation.
Physical and Chemical Properties
Octa-Arm PEG exhibits typical PEG properties, including excellent water solubility and low immunogenicity. The eight hydroxyl groups allow for further modification via esterification, etherification, or click chemistry. Its molecular weight can be tailored from 5,000 to 40,000 g/mol, influencing viscosity and gelation behavior. The compound is stable under ambient conditions but may degrade under prolonged exposure to strong acids/bases or UV light. Its melting point (~55–60°C) and solubility profile make it compatible with aqueous and organic processing methods, such as solvent casting or freeze-drying.
Main Applications
In drug delivery, Octa-Arm PEG forms hydrogels that encapsulate therapeutics, enabling sustained release. Its arms can be conjugated with active targeting ligands (e.g., peptides) for precision medicine. Researchers also use it to create synthetic extracellular matrices for 3D cell culture, mimicking tissue environments. Industrial applications include surface modification of medical devices to reduce fouling. In diagnostics, it improves nanoparticle stability and biocompatibility. The compound’s versatility extends to photolithography, where it acts as a bioink for printing scaffolds.
Safety and Storage
Octa-Arm PEG is generally recognized as safe (GRAS) for biomedical use but requires proper handling to maintain integrity. Powdered forms may cause mild irritation upon inhalation; use fume hoods and masks. Store at 2–8°C in moisture-proof containers to prevent hydrolysis. Disposal should follow local regulations for non-hazardous polymers. For large-scale use, conduct biocompatibility testing (e.g., ISO 10993) to ensure compliance with specific application standards, such as implantable devices.
B2B Procurement Guide
When sourcing Octa-Arm PEG, prioritize suppliers with GMP certification for biomedical-grade material. Key specifications include polydispersity index (<1.2), endotoxin levels (<0.1 EU/mg), and residual solvent content. Bulk buyers should request batch-specific COA and NMR/HPLC data. Lead times vary; custom molecular weights may require 4–8 weeks. Consider partnerships with manufacturers offering technical support for conjugation protocols. For cost efficiency, explore volume discounts or long-term contracts, especially for research consortia.
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