Overview
Phthalaldehyde (OPA) is an aromatic dialdehyde with significant applications in disinfection and biochemistry. Its high reactivity and fluorescent properties make it valuable in medical and laboratory settings. Originally developed as an alternative to glutaraldehyde, OPA is now a staple in high-level disinfection processes. In industrial contexts, OPA is synthesized through the oxidation of o-xylene or phthalic acid derivatives. Its purity is critical for efficacy, with pharmaceutical-grade OPA typically exceeding 98% purity. The compound’s versatility extends to protein cross-linking and histological staining, where its rapid action and low toxicity are advantageous.
Physical and Chemical Properties
Phthalaldehyde appears as a pale yellow crystalline solid or liquid, depending on temperature and formulation. It emits a distinct aromatic odor and exhibits strong fluorescence under UV light, a property exploited in biochemical assays. The compound’s density of 1.19 g/cm³ and boiling point of 266°C reflect its stability under standard conditions. OPA’s solubility profile includes water, alcohols, and common organic solvents like dimethyl sulfoxide (DMSO). Its reactivity with primary amines forms fluorescent derivatives, enabling applications in protein quantification. However, this reactivity necessitates careful handling to prevent degradation or unintended polymerization.
Main Applications
OPA’s primary use is as a high-level disinfectant for medical instruments, particularly endoscopes, where it outperforms glutaraldehyde in safety and speed. Its 5-12 minute contact time and non-fixative properties preserve delicate equipment. In biochemistry, OPA derivatives are used to label amino acids and peptides for HPLC analysis. The compound also serves as a cross-linker in polymer chemistry and a staining agent for electron microscopy. Emerging applications include wastewater treatment, where it neutralizes odor-causing compounds. Pharmaceutical formulations may incorporate OPA for its antimicrobial properties, though regulatory approvals vary by region.
Safety and Storage
OPA requires stringent safety measures due to its corrosive nature and potential respiratory sensitization. Personnel must wear nitrile gloves, goggles, and respirators when handling concentrated solutions. Spills should be neutralized with sodium bisulfite and contained with inert absorbents. Storage recommendations include amber glass or HDPE containers at 15-25°C, with nitrogen blanketing to prevent oxidation. Shelf life typically exceeds two years when protected from light and humidity. Transport regulations classify OPA as a Class 8 corrosive material, requiring UN-certified packaging for bulk shipments.
B2B Procurement Guide
Industrial buyers should prioritize suppliers with ISO 9001 certification and batch-specific Certificates of Analysis (CoA). Key specifications include purity (≥98%), heavy metal content (<10 ppm), and residual solvent levels. Packaging options range from 25 kg drums to custom bulk containers for large-scale users. Regional regulations impact procurement; for example, EU REACH compliance is mandatory for European importers. Sample testing for fluorescence efficiency and microbial validation is advised before large purchases. Long-term contracts with price adjustment clauses can mitigate market volatility, especially for GMP-grade material.
Related Manufacturers
- 主营：羟基乙叉二膦酸、九水硫化钠、P507、油酸
- 主营：三甘醇、五氧化二钒、纯牛骨蛋白胨、邻苯二甲醛分析试剂、牛油脂肪酸、氯偏乳液、苄基胂酸、漂粉精、苯甲醇、草酸镍、磷酸、六氟磷酸钾、次氯酸钙、钯碳、草酸钛钾、粘土固化剂、福美钠、戊二醛、碳酸钡、硝酸异辛酯、二甲基二硫代氨基甲酸、四氧化三铅、氯化锌、松醇油、磺化油、氟化氢钾
- 主营：N-二羟乙基对甲苯胺、N-二异丙醇对甲苯胺、三甲基戊二醇、邻苯二甲醛、三甲基戊二醇二苯甲酸、羟基乙酸、柠檬酸铝、间二三氟甲苯、双酚F
- 主营：石竹素、中间体、邻氟氯苄、高藜芦胺、偏钒酸钠、油酸甲酯、油酸乙酯、氯碘甲烷、反-查耳酮、2-甲基哌嗪、2-糠酸甲酯、2-噻吩甲醛、2-乙基咪唑、四甲酸二酐、2-甲氧基丙烯、萘二甲酰亚胺、8-萘内酰亚胺、2-呋喃甲酸甲酯、4'-联苯二羧酸、对二甲氨基甲苯
- 主营：香豆素、铃兰花、家居香氛、99%纯度新铃兰醛、绿色香料、结晶玫瑰、理想香料、甲基硝基胍、异丁酸苯酯、溴代十四烷、a 碳酸酯齐聚物、聚脱氧核糖核酸、鲑鱼精、脱氧核糖核酸、四水合氟化镍、二苯并、邻氨基苯甲醇、L - 甲状腺素、蛋白胨、法尼醇、氰乙酸仲辛酯、52688-08-1、乙酸肉桂酯、十六烷基三甲基溴化铵、对甲苯磺酸
- 主营：羟基磷灰石头、二醋酸纤维素、甲基丙烯酸镁、邻苯二甲醛现货、间苯二甲酸二甲酯、苯代三聚氰胺、苄索氯铵、柏木脑、乳酸铵、咪唑、明胶、靛红酸酐、DL-苹果酸、异噻唑啉酮、抗氧化剂1135、海藻酸
- 主营：黑檀醇、丙烷三、龙涎酮、丁酸己酯、丙烯酸酯、茉莉内酯、三羟甲基、7-羟基香豆素、二乙氨基乙醇、半胱胺盐酸盐、乙基乙烯基醚、4-氟苯肼盐酸盐、叔丁基对苯二酚、优级支链烷基苯
- 主营：苯甲醇、抗冻剂、丙三醇、润滑剂、叶面肥、慢干溶剂、二甲基亚砜、二甲基乙酰胺、十二水硫酸铝钾
- 主营：异辛醇、乳化剂、乙烯醚、邻苯二甲醛、醚羧酸、脂肪醇、分散剂、染色助剂、聚乙二醇、异构醇醚、泊洛沙姆、椰油酰胺、基羟乙基、烷基糖苷、特辛基酚、聚氧乙烯、嵌段聚醚、单油酸酯、异构十三醇、丙烯磺酸钠、氢化蓖麻油、丙烯酰胺基、醇醚葡糖苷、低泡渗透剂、甲酯乙氧基、癸基葡糖苷
- 主营：架桥剂、YW100 锂萃取剂、端羧基液体丁腈橡胶、10-羟基癸酸、苯乙烯磷酸、肉豆蔻酸镁、硬脂酸钴、全氟三丁胺、乙烯基磷酸二乙酯、磷酸锰铁锂、β-磷酸三钙、十一烯酸、钨酸铝、1-乙炔基环已醇、间二异丙苯、锂硅合金、溴甲酚绿、生物活性玻璃、溴代海因树脂颗粒、红铝、龙涎酮、原丁酸三甲酯
- 主营：全氟三丁胺、二苄叉山梨醇、六氟丙烯二聚体、邻苯二甲醛、六氟环氧丙烷二聚体、异丙醇铝、纳米勃姆石、二异戊基硫醚、隐色结晶紫、邻菲罗啉
- 主营：甘氨酸、水苏糖、阻燃剂、邻苯二甲醛、硫酸锌、硫酸锆、硫酸锂、硫酸锶、硫酸锰、铝酸锌、1680-21-3、牛磺酸、褪黑素、磷酸铁、丙酸铵、苏云金、碳酸镁、麝香酮、肉桂醛、磷酸铝、王浆酸、椰油胺、赖氨酸、增塑剂、浸膏粉、乙氧基
- 主营：叔碳酸、十八醛、溶菌酶、邻苯二甲醛、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：化学品、香精香料、试剂、中间体、有机硅、橡胶树脂、催化剂、纳米材料
- 主营：甲基丙烯酸十二酯、甲基丙烯酸十六酯、甲基丙烯酸十八酯、邻苯二甲醛、丙烯酸十二酯、丙烯酸十六酯、丙烯酸十八酯、V50引发剂、偶氮二异丁咪唑啉盐酸盐、N-乙酰己内酰胺、硅烷偶联剂、双马来酰亚胺、马来酸酯、缩水甘油酯、缩水甘油醚、甲基咪唑、N-异丙基丙烯酰胺、金属萃取剂
- 主营：异丙醇、冰醋酸、化工原料、正庚烷、甲基环己烷、乙二醇、苯酚、江苏异丙醇、江苏化工原料、工业吡啶、工业苯酚、正丁醇、MIBK、无水乙醇、正己烷
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：防冻液、冰醋酸、乙二醇、高纯三氯、冰乙酸、纯吡啶、丙二醇、羟基苯、14丁二醇、3-丙三醇、四氢呋喃、环保乙腈、化工苯酚、1.4丁二醇、医用苯酚、工业苯酚、精制苯酚、价位四氢、乙腈工业、乙酸乙酯、吡啶化工、甲酸乙酯、吡啶工业、求购苯酚、实验乙腈
- 主营：杜仲素、对位酯、丙烯酸酯、邻苯二甲醛、二氧化硫脲、乙基麦芽酚、饲料添加剂、油酸基硬脂酸、二苯基硅二醇
- 主营：高铁酸钾
- 主营：邻苯二甲醛、全氟三丁胺、木质素、吉氏色素