Overview
o-Nitro Cinnamaldehyde is an organic compound belonging to the class of nitro-substituted aromatic aldehydes. It is primarily utilized as a versatile intermediate in pharmaceutical and fragrance industries due to its reactive aldehyde and nitro functional groups. The compound is synthesized through nitration of cinnamaldehyde, followed by purification. Its yellow crystalline form and distinct aromatic properties make it identifiable in laboratory and industrial settings.
Physical and Chemical Properties
o-Nitro Cinnamaldehyde exhibits a melting point of 100-102°C and is soluble in common organic solvents like ethanol and acetone but insoluble in water. The nitro group at the ortho position enhances its electrophilic character, making it suitable for nucleophilic substitution reactions. Its molecular structure (C9H7NO3) includes a conjugated system, contributing to its UV absorption and reactivity in synthetic applications. Stability is moderate, requiring protection from light and moisture to prevent decomposition.
Main Applications
In pharmaceuticals, o-Nitro Cinnamaldehyde serves as a precursor for antihypertensive and antimicrobial agents. Its nitro group facilitates further chemical modifications, such as reduction to amino derivatives. In fragrances, it contributes to woody or spicy notes due to its aromatic profile. Additionally, it is employed in organic synthesis for constructing complex molecules via condensation or cyclization reactions.
Safety and Storage
The compound is classified as an irritant, requiring gloves, goggles, and respiratory protection during handling. Avoid contact with skin or inhalation of dust. Storage recommendations include airtight containers in cool, dark environments. Incompatible with strong oxidizers and bases, which may cause hazardous reactions. Dispose of waste according to local chemical disposal regulations.
B2B Procurement Guide
Buyers should prioritize suppliers providing detailed Certificates of Analysis (CoA) specifying purity (≥98%) and impurities. Bulk purchases typically offer cost advantages, but verify batch consistency. Logistics considerations include temperature-controlled shipping for large quantities. Reputable suppliers often comply with ISO or GMP standards, ensuring reliability for industrial applications.
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