Overview
o-Acetoxyacetophenone is an aromatic ester derived from acetophenone, featuring both acetyl and carbonyl functional groups. It is primarily used as an intermediate in pharmaceutical and fine chemical synthesis. This compound is valued for its reactivity, enabling transformations such as hydrolysis or further acylation. Industrial production typically involves acetylation of 2-hydroxyacetophenone under controlled conditions.
Physical and Chemical Properties
The compound is a colorless to pale yellow liquid at room temperature, with a characteristic mild odor. Its molecular structure includes an acetoxy group (-OCOCH3) adjacent to a carbonyl group, contributing to its polarity and solubility in organic solvents. Key reactivity includes susceptibility to nucleophilic attack at the carbonyl carbon and hydrolysis under acidic or basic conditions. Stability is moderate, requiring protection from moisture and strong oxidizers.
Main Applications
o-Acetoxyacetophenone serves as a versatile building block in pharmaceuticals, particularly for synthesizing anti-inflammatory and analgesic agents. It is also employed in fragrance formulations, contributing to floral or fruity notes. In research, it acts as a precursor for heterocyclic compounds and catalysts. Its dual functionality allows for diverse chemical modifications, making it valuable in custom synthesis projects.
Safety and Storage
Handle with care: o-Acetoxyacetophenone may cause skin and eye irritation. Use gloves, goggles, and fume hoods to minimize exposure. In case of contact, rinse thoroughly with water. Store in tightly sealed containers under inert gas (e.g., nitrogen) to prevent degradation. Shelf life is typically 1-2 years when stored below 25°C in a dark, dry environment.
B2B Procurement Guide
When sourcing o-Acetoxyacetophenone, prioritize suppliers with documented quality control (e.g., HPLC analysis for purity ≥98%). Request batch-specific COAs (Certificates of Analysis) and MSDS. Bulk buyers should negotiate pricing for quantities over 100 kg, but confirm storage and handling capabilities. Consider regional suppliers to reduce logistics costs and lead times.
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