Overview
N,N-Diethylacrylamide (DEAA) is an acrylamide derivative widely used in polymer chemistry and material science. Its unique structure, featuring a diethylamino group attached to the acrylamide backbone, enables controlled polymerization and functional material design. First synthesized in the mid-20th century, DEAA gained prominence for its ability to form polymers with lower critical solution temperature (LCST) behavior, making it valuable for smart hydrogels and biomedical applications. It serves as a building block for stimuli-responsive polymers that react to temperature or pH changes.
Physical and Chemical Properties
DEAA is a low-viscosity liquid at room temperature with a faint amine-like odor. Its molecular weight of 127.19 g/mol and polar structure contribute to good solubility in both water and organic solvents like ethanol or acetone. The compound undergoes radical polymerization readily, often initiated by azobisisobutyronitrile (AIBN) or UV light. Its polymer, poly(N,N-diethylacrylamide), exhibits reversible phase transitions near 32-34°C, a property exploited in drug delivery systems. DEAA is stable under inert atmospheres but may polymerize spontaneously if exposed to contaminants or excessive heat.
Main Applications
DEAA's primary use is in synthesizing thermoresponsive polymers for biomedical and industrial applications. These polymers are integral to injectable hydrogels, where they gel at body temperature for controlled drug release or tissue engineering scaffolds. In research, DEAA copolymers are studied for sensors and membranes due to their tunable swelling properties. The chemical industry utilizes DEAA-based polymers as viscosity modifiers or coatings. Smaller quantities serve as intermediates in pharmaceutical synthesis, though this requires high-purity grades.
Safety and Storage
As a reactive monomer, DEAA requires careful handling. It is classified as an irritant (skin/eye) and may cause respiratory sensitization. Always work in a fume hood with nitrile gloves and chemical splash goggles. Storage demands oxygen-free environments—preferably under nitrogen in amber glass bottles. Add inhibitors like 4-methoxyphenol (MEHQ) to prevent polymerization during long-term storage. In case of spills, absorb with inert material (e.g., sand) and dispose as hazardous waste. Never mix with strong oxidizers due to fire risk.
B2B Procurement Guide
Industrial buyers should prioritize suppliers with ISO certification and batch-specific COAs (Certificates of Analysis). Key specifications include purity (≥98% for most applications), inhibitor content (typically 100-200 ppm MEHQ), and moisture levels (<0.5%). Bulk purchases (25+ kg) often reduce costs by 15-30%. Consider regional regulations—some countries require special permits for acrylamide derivatives. Reliable suppliers include TCI Chemicals, Sigma-Aldrich, and domestic specialty chemical distributors. Request SDS and stability data before large orders.
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