Overview
Nitrostyrene is an aromatic nitro compound derived from styrene, characterized by a reactive vinyl group adjacent to a nitro moiety. It serves as a versatile intermediate in fine chemical synthesis, particularly for pharmaceuticals like antimalarials and antihypertensives. Industrial production typically involves Henry reactions between benzaldehyde and nitromethane. As a B2B commodity, it is traded in bulk quantities (25kg drums or custom packaging) with purity grades ranging from 95% to 99%. Manufacturers often modify its derivatives for specialized applications, such as electron-transport materials in OLED displays.
Physical and Chemical Properties
Nitrostyrene exhibits moderate stability under standard conditions but may polymerize or decompose when exposed to heat (>100°C) or strong acids/bases. Its UV-Vis spectrum shows strong absorption at 260–280 nm due to the conjugated π-system. The nitro group confers electrophilicity, enabling nucleophilic attacks at the β-carbon position. The crystalline form has a monoclinic structure with hydrogen bonding between molecules. Thermal analysis (DSC) reveals an exothermic decomposition peak around 200°C, necessitating careful temperature control during handling. Solubility parameters make it compatible with common organic solvents like DMF and THF.
Main Applications
In pharmaceuticals, nitrostyrene scaffolds are precursors to β-blockers and vasodilators. The agrochemical industry uses it to synthesize fungicides with styrylquinoline structures. Its electron-withdrawing properties are exploited in materials science for conductive polymers and non-linear optical materials. Recent R&D focuses on catalytic asymmetric hydrogenations to produce chiral amines for APIs. Dye manufacturers utilize its chromophore to create azo dyes with enhanced lightfastness. Smaller quantities serve academic research as a model compound for studying nitroalkene reactivity.
Safety and Storage
Classified as a Category 3 irritant (GHS07), nitrostyrene requires gloves (nitrile), goggles, and respirators when handling powder. Storage recommendations include nitrogen-inerted containers at <30°C, segregated from oxidizers (peroxides, chlorates). Spills should be contained with inert absorbents like vermiculite. Decomposition products include nitrogen oxides, requiring fume extraction. Firefighting mandates alcohol-resistant foam—water alone may spread contamination. SDS documentation must address ecotoxicity (LC50 Daphnia magna: 12 mg/L) and disposal as hazardous waste (incineration with scrubbers).
B2B Procurement Guide
Bulk buyers should prioritize suppliers with ISO 9001 certification and batch-specific COAs analyzing residual solvents (e.g., methanol <0.5%). Spot purchases commonly involve EXW or FOB terms from Chinese/Indian producers, while contract manufacturing often requires cGMP compliance. Key due diligence points: verify stability data (accelerated aging tests), multi-step synthesis documentation, and transportation compliance (UN3077, PG III). Negotiate MOQs (typically 100kg+) for better pricing tiers. Third-party lab validation is advised for niche applications like electronics-grade material.
Related Manufacturers
- 主营：三甘醇二异辛酸酯3G8、三硫代碳酸钠40%、TS-1钛硅分子筛、聚乙烯亚胺、烷基苯磺酸酯、六氯环三磷腈、5-甲基靛红、苯基次磷酸钠、甲巯咪唑、吡啶硫酮锌、焦磷酸哌嗪、热敏材料、油酸甲酯、曲酸
- 主营：叔碳酸、十八醛、溶菌酶、硝基苯乙烯、海藻糖、癸二醇、氨基丙基、氢路噻嗪、邻苯二甲、乙基碳二、羟基癸酸、正十七烷、谷胱甘肽、烷二甲醇、松果体素、vc磷酸酯镁、2-甲基丁醛、朱栾倍半萜、丁烷四乙酸、表面活性剂、癸烷撑二醇、缩水甘油邻、10-羟基羊蜡酸、氢氯噻嗪杂质、盐酸邻菲罗啉、壳聚糖季铵盐
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：全氟聚醚二醇、全氟三丁胺、聚硅氮烷、硝基苯乙烯、特种硅油、特种硅树脂
- 主营：十六烷基磺酸钠、聚硅氧烷、新癸酸钕、医药中间体、巯基乙酸铵、甲氧基丙酮、表面活性剂、1.3环己二酮、三甲基溴化硫醚
- 主营：聚维酮碘、磺酸二钠盐、己二酰氯、间溴硝基苯、柠檬酸钴、溴化镍、氟化锌、焦锑酸钾、硫化钡、苯磺酰氯
- 主营：6485-39-8、2316-26-9、甘氨酸、硝基乙烯基苯、3189-13-7、4368-51-8、阻燃剂、红曲黄、1079-66-9、2920-38-9、3087-36-3、9012-76-4、127-47-9a、硫酸锰、4861-19-2、1313-96-8、3687-46-5、7659-86-1、7681-52-9、3458-28-4、吐温t20、牛磺酸、灭火剂、肉桂醇、1189-71-5、布龙酸
- 主营：生物素修饰蛋白、fitc标记蛋白、pvc微球、聚苯乙烯微球、嵌段共聚物、生物素标记、荧光标记、纳米颗粒、核苷糖、aie、复合微球、功能化载玻片、荧光染料、金属配合物、Mxene、介孔二氧化硅微球、磁性纳米颗粒、小分子PEG、聚合物、纳米金、聚合物微球、荧光微球、荧光探针、点击化学、小分子
- 主营：固体酸催化剂、重组胶原蛋白、硅油、硝基苯乙烯、特种硅油、聚硅氮烷、硼酸铝晶须、碳化硅晶须、t-BAMBP萃取剂、全氟三丁胺
- 主营：磺酰胺、氧化铌、除醛剂、硅化镱、基硅油、成核剂、酞菁钴、甘氨酸铬、光学树脂、鼠李糖脂、甲磺酸铋、氧化亚铁、封端硅油、左旋乳酸)、六水氯化钇、己基磺酸盐、恩诺沙星钠、二聚季戊四醇、聚醚硫酸酯钠、恶唑啉交联剂、洗手凝胶增稠剂、生物活性玻璃粉、氰基丙烯酸乙酯、脱硫脱氢催化剂
- 主营：石油加工助剂、乙二醇二醋酸酯、水性涂料成膜剂
- 主营：荧光素酶、血管紧张素转化酶、乳酸氧化酶、脱氧核糖核酸酶1型、乙酰胆碱酯酶、硫酸软骨素ABC酶、肝素酶
- 主营：N-二甲基烯丙基、氯化偏苯三酸酐
- 主营：羟甲基脲、溴化钾
- 主营：液体聚硫橡胶、氮丙啶交联剂、异山梨醇二甲醚、氧化石蜡皂、水杨羟肟酸、乙二胺磷酸盐