Overview
Nitroindolone (5-Nitroindolin-2-one) is an organic compound belonging to the class of nitro-substituted heterocycles. It serves as a versatile intermediate in pharmaceutical and agrochemical synthesis. The nitro group at the 5-position of the indolone scaffold makes it a valuable precursor for further functionalization, particularly in the development of bioactive molecules. As a research chemical, nitroindolone is primarily used in academic and industrial laboratories for drug discovery projects. Its structure is a key motif in compounds targeting neurological and inflammatory pathways. The compound is typically supplied as a crystalline solid with purity levels ranging from 95% to 99% for laboratory use.
Physical and Chemical Properties
Nitroindolone exhibits characteristic properties of aromatic nitro compounds, including moderate stability under standard conditions. The crystalline powder shows limited solubility in water but dissolves readily in polar organic solvents like dimethyl sulfoxide (DMSO) and ethanol. Thermal analysis indicates decomposition rather than boiling at elevated temperatures. The nitro group confers strong electron-withdrawing effects, making the compound reactive in reduction reactions and nucleophilic substitutions. UV-Vis spectroscopy typically shows absorption maxima around 260-280 nm due to the conjugated system. Handling requires caution as the compound may form explosive mixtures under extreme conditions (e.g., high temperatures with reducing agents).
Main Applications
In pharmaceutical manufacturing, nitroindolone serves as a building block for indole-derived active pharmaceutical ingredients (APIs). It is particularly valuable in synthesizing kinase inhibitors and serotonin receptor modulators. Researchers utilize its nitro group for subsequent transformations into amines, amides, or heterocyclic fused systems. The compound also finds niche applications in material science, where its aromatic structure contributes to the development of organic semiconductors and photoactive materials. Agrochemical companies may employ nitroindolone derivatives in pesticide formulations, though such uses are less common than pharmaceutical applications.
Safety and Storage
As a nitroaromatic compound, nitroindolone requires careful handling to prevent health risks and stability issues. Laboratory personnel should use appropriate personal protective equipment (PPE), including nitrile gloves, safety goggles, and fume hoods when handling the powder. Skin contact may cause irritation, and inhalation of dust should be avoided. For long-term storage, the compound should be kept in amber glass containers with desiccants to minimize moisture absorption. Storage temperatures between 2-8°C are recommended for extended shelf life. Incompatible with strong oxidizers and reducing agents, nitroindolone should be segregated from these materials in storage areas.
B2B Procurement Guide
When sourcing nitroindolone for industrial or research purposes, buyers should prioritize suppliers with documented quality control processes. Key specifications to verify include HPLC purity (typically ≥95%), residual solvent content, and batch-to-batch consistency. Pharmaceutical-grade material requires additional documentation like Certificate of Analysis (CoA) and compliance with ICH guidelines. Lead times may vary significantly depending on quantity and purity requirements. For bulk procurement (kilogram scale), expect 4-8 weeks for custom synthesis and quality testing. Consider requesting samples for analytical verification before large purchases. International shipments may require special hazardous material documentation due to the compound's classification.
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