Overview
Nitroxoline Powder, chemically known as 5-Nitro-8-hydroxyquinoline, is a synthetic antibacterial agent primarily used to treat urinary tract infections caused by Gram-negative bacteria. It belongs to the hydroxyquinoline class of compounds and is known for its efficacy and relatively low toxicity. Nitroxoline was first synthesized in the mid-20th century and has since been used in various medical applications. Its antibacterial properties make it a valuable component in pharmaceutical formulations, particularly in regions where urinary tract infections are prevalent.
Physical and Chemical Properties
Nitroxoline Powder appears as a yellow to yellowish-brown crystalline powder. It has a molecular weight of 190.15 g/mol and a melting point of approximately 220-225°C, at which point it decomposes. The compound is slightly soluble in water but dissolves more readily in ethanol and dilute acids. The antibacterial activity of Nitroxoline is attributed to its ability to chelate metal ions, disrupting bacterial metabolic processes. Its stability under normal storage conditions makes it suitable for long-term use in pharmaceutical formulations.
Main Applications
Nitroxoline Powder is primarily used in the treatment of urinary tract infections (UTIs), especially those caused by Gram-negative bacteria such as Escherichia coli. It is often formulated into tablets or capsules for oral administration. Beyond its medical uses, Nitroxoline is also employed in research settings to study bacterial resistance mechanisms and the effects of hydroxyquinoline derivatives on microbial growth. Its broad-spectrum activity makes it a versatile tool in both clinical and laboratory environments.
Safety and Storage
Nitroxoline Powder should be handled with care to avoid inhalation or direct skin contact. Proper personal protective equipment (PPE), including gloves and masks, is recommended during handling. The compound should be stored in a cool, dry place, away from light and moisture, to maintain its stability. In case of accidental exposure, rinse the affected area with plenty of water and seek medical advice. Nitroxoline is generally safe when used as directed, but improper handling can lead to irritation or allergic reactions.
B2B Procurement Guide
When procuring Nitroxoline Powder, it is essential to verify the supplier's compliance with pharmaceutical-grade standards. Look for certifications such as Good Manufacturing Practice (GMP) to ensure product quality and safety. The reference price range for Nitroxoline Powder is approximately $50-$100 per kilogram, though prices may vary based on quantity and supplier. Bulk purchases often attract discounts, but buyers should prioritize quality over cost to avoid substandard products.
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