Overview
Nitroacetophenone, also known as 4-nitroacetophenone, is a nitro-substituted aromatic ketone. It is widely used as a building block in organic synthesis, particularly in the production of pharmaceuticals and dyes. The compound is characterized by its yellow crystalline appearance and distinct reactivity due to the presence of both nitro and carbonyl functional groups. Its synthesis typically involves the nitration of acetophenone, followed by purification. The compound's stability and reactivity make it a versatile intermediate in various chemical processes, though it requires careful handling due to its irritant properties.
Physical and Chemical Properties
Nitroacetophenone exhibits a melting point of 78-80°C and a density of 1.20 g/cm³. It is soluble in organic solvents like ethanol and acetone but has limited solubility in water. The nitro group enhances its electrophilic properties, making it useful in substitution reactions. The compound's aromatic ring and nitro group contribute to its stability under standard conditions, though it may decompose under prolonged exposure to heat or light. Its reactivity is often exploited in synthetic chemistry to produce more complex molecules, such as pharmaceuticals or agrochemicals.
Main Applications
Nitroacetophenone is primarily used in the pharmaceutical industry as an intermediate for drugs like antihistamines and analgesics. Its nitro group can be reduced to an amine, which is a common step in drug synthesis. In the dye industry, it serves as a precursor for azo dyes, which are widely used in textiles and printing. Additionally, it finds applications in organic synthesis for producing specialty chemicals, including fragrances and flavoring agents.
Safety and Storage
Nitroacetophenone is classified as an irritant and should be handled with care. Direct contact with skin or eyes can cause irritation, so personal protective equipment (PPE) such as gloves and goggles is essential. Storage should be in a cool, dry place, away from light and oxidizing agents. Containers must be tightly sealed to prevent moisture absorption or contamination. In case of spills, absorb with inert material and dispose of according to local regulations.
B2B Procurement Guide
When procuring nitroacetophenone, verify the CAS number (100-19-6) and purity level, typically 98% or higher for industrial use. Reputable suppliers should provide material safety data sheets (MSDS) and certificates of analysis (CoA). Bulk buyers should inquire about packaging options (e.g., 25 kg drums) and shipping conditions to ensure product integrity. Prices vary based on quantity and supplier, but expect a range of $50-$100/kg for reference. Long-term contracts may offer cost advantages.
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