Overview
Nimorazole is a nitroimidazole-class compound developed as a radiosensitizer to enhance the effects of radiation therapy in cancer treatment. It selectively targets hypoxic (oxygen-deprived) tumor cells, which are typically resistant to radiation. First synthesized in the 1960s, it has been clinically studied for head and neck cancers, though its adoption varies by region due to regulatory approvals. Unlike other nitroimidazoles, nimorazole exhibits lower neurotoxicity, making it a candidate for combination therapies. Its mechanism involves free radical formation under hypoxic conditions, damaging DNA in radioresistant cells. Research continues to explore its efficacy in other solid tumors.
Physical and Chemical Properties
Nimorazole appears as a white crystalline powder with moderate solubility in water and ethanol, facilitating formulation for oral or intravenous administration. Its molecular structure includes a nitro group (–NO2) critical for its radiosensitizing activity, linked to an imidazole ring and a methoxyethyl side chain. Stability tests indicate it degrades under prolonged exposure to light or high humidity, necessitating airtight, opaque packaging. The compound’s melting point (92–94°C) and partition coefficient (log P ≈ 0.5) reflect its balanced hydrophilicity-lipophilicity, influencing pharmacokinetics.
Main Applications
In clinical oncology, nimorazole is primarily used as an adjunct to radiotherapy for head and neck squamous cell carcinoma (HNSCC), notably in European protocols. The DAHANCA trials demonstrated its ability to improve locoregional tumor control by 10–15% in hypoxic tumors. Beyond oncology, research explores its antimicrobial potential against anaerobic pathogens, though this remains experimental. Its B2B demand stems from pharmaceutical manufacturers and research institutions requiring GMP-grade material for trials or production.
Safety and Storage
Nimorazole is classified as a potential mutagen (Category 2 under EU CLP regulations). Handling requires gloves, goggles, and fume hoods to avoid inhalation or skin contact. Spills should be neutralized with absorbent materials and disposed of as hazardous waste. Long-term storage mandates temperatures below 25°C in amber glass containers with desiccants. Stability studies suggest a shelf life of 24 months when stored properly, though batch-specific testing is recommended for critical applications.
B2B Procurement Guide
Buyers should prioritize suppliers with ISO-certified facilities, offering certificates of analysis (CoA) detailing purity (≥98%), residual solvents, and heavy metal content. Bulk purchases (1 kg+) commonly attract 10–20% discounts, but confirm cold-chain logistics for temperature-sensitive shipments. Regulatory compliance varies: While nimorazole is approved in the EU for HNSCC, FDA clearance is pending. Verify end-use regulations to avoid customs issues. Spot prices fluctuate based on API market trends; consider contracts with price-adjustment clauses.
Related Manufacturers
- 主营：砷酸锂、白云石、水合物、氮化锌、144205-68-5、二叔丁基、利多卡因、碳化钨钴、泛影葡胺、化合物库、1093222-27-5、羟基苯基、八钼酸铵、生化试剂、苯甲酸乙酯、熊去氧胆酸、胆酸二水合、乙酰丙酮锌、湿法云母粉、六氟磷酸盐、干法云母粉、苯碳酸甲酯、脱氧胆酸二水、氨基二琥珀酸、对乙酰氨基苯酚
- 主营：赤霉素、溴苯基、联噻吩、恶唑烷、咪唑并、咪唑乙醇、溴喹唑啉、果糖嗪、屎米酮、碘吡啶、氟苯基、安美速、s-4-苄基、3-溴吲哚、4-氯吡啶、1-乙酸基、氯苯甲酸、氧代丙腈、贝达喹啉、贝伐单抗、谷氨酰胺、喹啉-21氢、决明内酯、苯基丙基、乙基己基
- 主营：甘氨酸、甘氨酰、苯硫醚、尼莫拉唑6506、阻燃剂、月桂胺、酸性橙、去铁酮、豆油酸、二苯胺、西瓜酮、八乙基、硫酸锆、磺化钯、二氰基、硫酸锶、硫酸锰、二苯胍、铝酸锶、聚合物、肌氨酸、四氢萘、磷酸铵、甲乙基、甲基亚、碳酸镁