Overview
Nicarbazin is a synthetic chemical compound widely used in the poultry industry as a coccidiostat. It is particularly effective against Eimeria species, the parasites responsible for coccidiosis in chickens. The compound is typically administered through feed to prevent outbreaks of this economically significant disease. First introduced in the 1950s, Nicarbazin has become a staple in poultry health management due to its efficacy and relatively low toxicity when used as directed. It is often combined with other feed additives to enhance its anticoccidial effects.
Physical and Chemical Properties
Nicarbazin appears as a yellow crystalline powder with a molecular weight of 302.24 g/mol. It is slightly soluble in water but dissolves well in organic solvents like dimethyl sulfoxide (DMSO). The compound decomposes at temperatures around 265-270°C, making it stable under normal storage and handling conditions. Its chemical structure includes nitro groups, which contribute to its anticoccidial activity. The stability of Nicarbazin in feed matrices ensures consistent delivery of the active ingredient to poultry, maximizing its therapeutic effects.
Main Applications
The primary application of Nicarbazin is in the prevention and control of coccidiosis in chickens. It is incorporated into poultry feed at controlled doses to inhibit the growth and reproduction of Eimeria parasites. The compound is particularly effective against Eimeria tenella and Eimeria necatrix, two of the most pathogenic species. Nicarbazin is often used in rotation with other coccidiostats to prevent the development of resistance. Its use is strictly regulated in many countries, with withdrawal periods mandated before birds are slaughtered for human consumption.
Safety and Storage
Nicarbazin should be handled with care to avoid inhalation or skin contact. Personal protective equipment, including gloves and masks, is recommended during handling. The compound is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight to maintain its efficacy. In terms of environmental safety, Nicarbazin should not be released into waterways or soil. Proper disposal methods must be followed to minimize environmental impact. Regulatory guidelines on its use in poultry feed must be strictly adhered to ensure food safety.
B2B Procurement Guide
When procuring Nicarbazin, B2B buyers should verify the CAS number (330-95-0) to ensure they are purchasing the correct compound. Purity levels, typically ranging from 98% to 99%, should be confirmed with the supplier. Buyers should also check for compliance with local and international regulations, such as FDA or EU standards. Price ranges can vary significantly based on quantity, purity, and supplier reputation. Bulk purchases often come with discounts, but buyers should balance cost with quality assurance. Establishing long-term relationships with reputable suppliers can ensure consistent quality and reliable supply chains.
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