Nattokinase Extract
Overview
Nattokinase Extract is a potent fibrinolytic enzyme derived from Bacillus subtilis var. natto, the bacterium used in fermenting natto, a traditional Japanese food. It was first isolated in the 1980s and has since gained attention for its potential cardiovascular benefits. The enzyme exhibits strong thrombolytic activity, making it a popular ingredient in dietary supplements aimed at supporting circulatory health. Nattokinase is produced through fermentation and subsequent extraction and purification processes. Its fibrinolytic properties are comparable to those of plasmin, a natural enzyme in the human body that dissolves blood clots. Unlike some pharmaceutical thrombolytics, nattokinase is orally active and has a longer duration of action.
Physical and Chemical Properties
Nattokinase Extract typically appears as a light yellow to white powder with high solubility in water. Its molecular weight ranges between 27-28 kDa, and it functions optimally at a pH of 6.0-8.0. The enzyme is relatively stable under moderate heat, retaining activity at temperatures up to 60°C, but degrades rapidly above 70°C. One of the key properties of nattokinase is its fibrinolytic activity, measured in fibrinolytic units (FU). High-purity extracts can achieve activities exceeding 20,000 FU per gram. The enzyme’s stability under various pH conditions makes it suitable for incorporation into a wide range of formulations, including capsules, tablets, and functional foods.
Main Applications
Nattokinase Extract is primarily used in the dietary supplement industry, where it is marketed for its potential to support cardiovascular health. It is commonly found in products aimed at improving blood circulation, reducing blood viscosity, and preventing clot formation. Some studies suggest it may help maintain healthy blood pressure levels. In addition to supplements, nattokinase is being explored for pharmaceutical applications, particularly in thrombolytic therapy. Its ability to dissolve fibrin clots without significant side effects makes it a promising candidate for further research. Functional foods and beverages fortified with nattokinase are also emerging in markets focused on preventive healthcare.
Safety and Storage
Nattokinase Extract is generally considered safe for consumption, with no significant adverse effects reported at recommended dosages. However, individuals with bleeding disorders or those taking anticoagulant medications should exercise caution, as the enzyme may enhance the effects of blood-thinning drugs. Proper storage is essential to maintain the enzyme’s activity. It should be kept in a cool, dry environment, ideally below 25°C, and protected from moisture and direct sunlight. Bulk quantities are often packaged in airtight containers with desiccants to prolong shelf life, typically up to two years when stored correctly.
B2B Procurement Guide
When sourcing Nattokinase Extract for commercial use, it is critical to evaluate suppliers based on enzyme activity (FU/g), purity, and compliance with quality standards such as GMP or ISO certification. Reputable suppliers provide certificates of analysis (CoA) detailing potency, microbial limits, and heavy metal content. Bulk buyers should negotiate pricing based on volume, with prices commonly ranging from $50 to $200 per kilogram. Consider suppliers offering customized formulations or private labeling services if branding is a priority. Sampling and third-party testing are recommended to ensure product consistency and efficacy before large-scale procurement.
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