Overview
Nattokinase is a serine protease enzyme extracted from natto, a fermented soybean product traditionally consumed in Japan. It was first isolated in the 1980s and has since gained attention for its potent fibrinolytic activity, which helps dissolve blood clots. Unlike other fibrinolytic agents, nattokinase is orally active and has a longer half-life, making it suitable for dietary supplements. This enzyme is produced through the fermentation of soybeans by Bacillus subtilis var. natto. The fermentation process enhances its bioactivity and stability. Nattokinase is widely used in the nutraceutical industry due to its cardiovascular benefits, including improving blood circulation and reducing the risk of thrombosis.
Physical and Chemical Properties
Nattokinase is a white to off-white powder with a molecular weight of approximately 27,700 Daltons. It is soluble in water and exhibits optimal activity at a pH range of 6.0-8.0. The enzyme is relatively heat-stable, retaining activity at temperatures up to 60°C, but prolonged exposure to higher temperatures can denature it. One of its key properties is its fibrinolytic activity, which is measured in fibrinolytic units (FU). High-purity nattokinase typically has an activity of 20,000-40,000 FU/g. The enzyme is also stable under acidic conditions, allowing it to survive the stomach environment and remain active in the bloodstream.
Main Applications
Nattokinase is primarily used in dietary supplements aimed at supporting cardiovascular health. Its ability to break down fibrin, a key component of blood clots, makes it valuable for preventing and managing conditions like deep vein thrombosis, hypertension, and atherosclerosis. Beyond supplements, nattokinase is incorporated into functional foods and beverages, such as health drinks and fortified snacks. Research is also exploring its potential in medical applications, including as an adjunct therapy for stroke prevention. Its natural origin and safety profile make it a preferred choice over synthetic anticoagulants.
Safety and Storage
Nattokinase is generally considered safe for consumption, with no significant side effects reported at recommended doses. However, individuals taking blood-thinning medications (e.g., warfarin) should consult a healthcare professional before use, as it may enhance anticoagulant effects. Proper storage is essential to maintain its activity. The enzyme should be kept in a cool, dry place below 25°C, away from moisture and direct sunlight. Bulk quantities are often packaged in airtight containers with desiccants to prevent degradation. Stability testing should be conducted to ensure product quality over time.
B2B Procurement Guide
When sourcing nattokinase, B2B buyers should prioritize suppliers with certifications such as GMP (Good Manufacturing Practice) and ISO (International Organization for Standardization). Key specifications to verify include enzyme activity (FU/g), purity (typically >95%), and absence of contaminants like heavy metals or microbial pathogens. Price varies based on purity and activity levels, with higher-grade products commanding premium prices. Buyers should request certificates of analysis (CoA) and consider conducting third-party testing for quality assurance. Long-term partnerships with reputable suppliers can ensure consistent quality and reliable supply chains.
Related Manufacturers
- 主营：十六烷基三甲基溴化铵、十二烷基甜菜咸、乳化剂、亚磷酸三丁酯、棕榈油、钛酸四丁酯、钛酸四乙酯
- 主营：全氟三丁胺、全氟三乙胺、全氟三丙胺、纳豆菌胶、全氟聚醚、全氟萘烷、全氟己酮、羟基磷灰石、生物活性玻璃、布洛芬、溴壬烷、磷酸铵、甲乙基、褪黑素、嘧啶钠、莪术油、显色剂、叔丁醇、茜素红、乙氧基、异戊醇、脯氨酸、茚三酮、氯唑沙
- 主营：硫酸钡、覆盆子酮、胍基丙酸、早强防冻剂、食品级磷酸镁、二肌酸苹果酸、苯基膦酰二氯、食品级硫酸镁、二肌酸柠檬酸
- 主营：环戊酮、甲酸镍、阻燃剂、草酸镧、钼酸铵、催化剂、钒酸铋、溴氨酸、硝酸锆、碳酸镧、白僵菌、磷酸铁、钨酸酐、氟化镧、视黄醇、叔丁醇、杀螨剂、杀虫剂、醋酸钬、抗粘剂、氟化镥、肟菌酯、氢化钠、氯铂酸、氟化镁
- 主营：L-精氨酸、L-抗坏血酸、甘氨酸、威兰胶、古尔胶、瓜尔胶、瓜尔豆胶、半胱氨酸、维生素C/vc、核黄素(维生素B2)、胍基乙酸、牛磺酸、L-蛋氨酸、L-半胱氨酸、L-半胱氨酸盐酸盐、工业级VC、L-谷氨酰胺、L-苯丙氨酸、DL-蛋氨酸、L-丙氨酸、酪蛋白酸钠、酪蛋白/干酪素、海藻酸钠/海藻酸钠、硒代蛋氨酸、烟酸/烟酰胺
- 主营：福美钠、五氧化二钒、氨基磺酸、纳豆菌胶、氨基化锂、焦性没食子酸、次氯酸钙、漂粉精、酪蛋白胨、甘油、九水硫化钠、牛油脂肪酸、酵母膏、氟硅酸钠、单乙醇胺、氢氧化钾、氟化钠、氟化钙、氧化铅、油酸钠、偏钒酸铵、氢氧化钡、EVA乳液、二硫化钼、氟化氢钾
- 主营：合成树脂、固化剂、不饱和树脂、纳豆菌胶、环氧树脂、聚酯多元醇、酚醛树脂、医药中间体
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：二氧化硒、对甲苯磺酸、黄血盐钠、黄血盐钾、苯甲酸、环烷酸、戊二醛、磺化钛氰钴、盐酸羟胺、过氧化苯甲酰、衣康酸、聚丙烯酸酯乳液、癸甲溴铵、癸甲氯铵、4丁炔二醇、马日夫盐、氟硅酸镁、聚乙烯吡咯烷酮k30、磷酸三丁酯、聚六亚甲基双胍、黄丹粉、红丹粉、牛肉浸膏、HEDP
- 主营：硫酸铜、二甲苯、均染剂、纳豆菌胶、钼酸铵、液体肥、硫酸锌、乳化剂、锡酸钠、发黑液、叶面肥、混合菌、高碳醇、硫酸钴、络合剂、除油粉、糖醇锌、醋酸铜、氯化钾、壳寡糖、叔丁醇、清洗剂、糖醇硅、海藻硼、醋酸钴、防锈油
- 主营：18908-66-2、癸甲氯铵、咪唑烷酮、二异丁腈、饲料添加剂、分散剂工业、柠檬酸三丁酯、聚乙烯吡咯烷、二甲基溴化铵
- 主营：三甘醇、五氧化二钒、纯牛骨蛋白胨、纳豆菌胶、牛油脂肪酸、氯偏乳液、苄基胂酸、漂粉精、苯甲醇、草酸镍、磷酸、六氟磷酸钾、次氯酸钙、钯碳、草酸钛钾、粘土固化剂、福美钠、戊二醛、碳酸钡、硝酸异辛酯、二甲基二硫代氨基甲酸、四氧化三铅、氯化锌、松醇油、磺化油、氟化氢钾
- 主营：增溶剂、聚乙二醇、泊洛沙姆、枝共聚物、微晶纤维素、聚醋酸乙烯酯、羟基硬脂酸酯、聚乙烯己内酰胺
- 主营：葛根提取物、姜黄素、羊奶粉、胶原三肽、鱼油、蝶豆花粉、魔芋精粉、牦牛骨肽、蓝莓粉、破壁松花粉、藤黄果提取物、椰子油粉、甘草酸二钾、β-胡萝卜素、亚麻籽油微囊粉、叶黄素、槲皮素、葛根黄酮、苯乙基间苯二酚、光甘草定、蓝莓花青素、中链甘油三酯、共轭亚油酸粉、玉米肽、沙棘冻干粉
- 主营：磷酸三钙、钡玻璃粉、锶玻璃粉、虫胶粉/精制紫胶、磺化栲胶、异戊橡胶、杜仲胶、水解胶原蛋白锌、生物活性玻璃、全氟三丁胺、卡波姆树脂、月桂酰赖氨酸、木瓜蛋白酶、低温玻璃粉、聚酰亚胺pi树脂微粉、八甘醇、羟基磷灰石、高取代羟丙基纤维素、二水硫酸钙、壳聚糖、氢化卵磷脂、辛烯基琥珀酸淀粉钠、花椒麻素、甲氧基聚乙二醇丙烯酸、维生素A棕榈酸酯