Overview
N-Methylmethoxyacetamide (NMMA) is an organic compound with the molecular formula C4H9NO2. It is commonly used as a solvent and intermediate in pharmaceutical and agrochemical industries. The compound's unique structure, featuring both amide and ether functional groups, makes it valuable in various synthetic applications. NMMA is known for its high polarity and ability to dissolve a wide range of organic compounds. Its stability under normal conditions and relatively low toxicity profile contribute to its widespread use in industrial applications. The compound is typically supplied as a colorless to pale yellow liquid.
Physical and Chemical Properties
N-Methylmethoxyacetamide is a polar aprotic solvent with a molecular weight of 103.12 g/mol. It has a density of approximately 1.02 g/cm³ and boils at around 180-185°C. The compound is miscible with water and most common organic solvents, including alcohols, ethers, and chlorinated hydrocarbons. The chemical exhibits good thermal stability under normal conditions but may decompose at elevated temperatures. Its polar nature makes it particularly useful in reactions requiring polar solvents. The presence of both electron-donating (methoxy) and electron-withdrawing (amide) groups in its structure contributes to its unique solvent properties.
Main Applications
In the pharmaceutical industry, NMMA serves as a valuable intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Its ability to participate in diverse chemical reactions makes it particularly useful in medicinal chemistry. The agrochemical sector utilizes NMMA in the production of pesticides and herbicides. Its solvent properties are beneficial in formulation processes. Additionally, the compound finds use in organic synthesis as a reagent and solvent for various transformations, including nucleophilic substitutions and condensations.
Safety and Storage
While N-Methylmethoxyacetamide is not classified as highly hazardous, proper safety precautions should be observed. The compound may cause skin and eye irritation upon contact, and inhalation of vapors should be avoided. Appropriate personal protective equipment (PPE) including gloves and safety goggles is recommended when handling this chemical. Storage should be in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and open flames. The chemical is generally stable but should be kept away from strong oxidizing agents. Shelf life is typically 2-3 years when stored properly.
B2B Procurement Guide
When procuring N-Methylmethoxyacetamide, buyers should verify the CAS number (78191-00-1) to ensure product authenticity. Key specifications to check include purity level (typically 98% or higher), water content, and absence of impurities. Reliable suppliers should provide certificates of analysis (CoA) and material safety data sheets (MSDS). Bulk purchases may offer cost advantages, but buyers should consider storage capabilities. Technical grade is often sufficient for industrial applications, while pharmaceutical grade commands premium pricing. Lead times may vary based on supplier location and current demand.
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