Overview
N-Hydroxyethylphthalimide (HEP) is an organic compound derived from phthalimide, featuring a hydroxyethyl group attached to the nitrogen atom. It is widely used as an intermediate in pharmaceutical synthesis and material science. HEP is valued for its reactivity and stability, making it suitable for various chemical transformations. Its applications span across industries, particularly in the development of active pharmaceutical ingredients (APIs) and specialty polymers.
Physical and Chemical Properties
N-Hydroxyethylphthalimide appears as a white to off-white crystalline powder with a molecular weight of 207.18 g/mol. It has a melting point range of 120-125°C and is soluble in common organic solvents like ethanol and acetone. The compound is stable under normal conditions but may degrade when exposed to strong acids, bases, or oxidizing agents. Its solubility profile and thermal stability make it a versatile reagent in organic synthesis.
Main Applications
HEP is primarily used as a building block in pharmaceutical synthesis, particularly for APIs and drug intermediates. It serves as a precursor in the production of various therapeutic agents. In material science, HEP is employed to modify polymers, enhancing their properties for specific applications. Its reactivity allows for the introduction of functional groups, making it valuable in specialty chemical formulations.
Safety and Storage
N-Hydroxyethylphthalimide may cause skin and eye irritation upon contact. Proper personal protective equipment (PPE), including gloves and safety goggles, is recommended when handling the compound. Storage should be in a cool, dry place, away from direct sunlight and moisture. Containers must be tightly sealed to prevent contamination and degradation. Ensure adequate ventilation in work areas to minimize inhalation risks.
B2B Procurement Guide
When procuring N-Hydroxyethylphthalimide, verify the CAS number (1875-50-9) to ensure product authenticity. Request material safety data sheets (MSDS) and certificates of analysis (CoA) from suppliers. Consider purity requirements based on your application. Prices typically range from $50 to $100 per kilogram, depending on quantity and supplier. Bulk purchases may offer cost advantages, but ensure proper storage conditions are maintained post-purchase.
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