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N-Cyclohexylaniline

Updated: 2026-07-17

Overview

N-Cyclohexylaniline is an organic compound derived from the reaction of cyclohexylamine with aniline. It is primarily used as an intermediate in chemical synthesis, particularly in the pharmaceutical and agrochemical industries. The compound exhibits weak basicity and is stable under normal conditions, making it suitable for various industrial applications. Its synthesis typically involves the alkylation of aniline with cyclohexyl halides or other cyclohexylating agents. The purity of N-Cyclohexylaniline is critical for its effectiveness in downstream processes, and it is often supplied in liquid form with varying degrees of purity depending on the intended use.

Physical and Chemical Properties

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N-Cyclohexylaniline is a colorless to pale yellow liquid with a molecular weight of 175.27 g/mol. It has a density of approximately 0.98 g/cm³ and a boiling point ranging between 250-260°C. The compound is soluble in common organic solvents such as ethanol and ether but is insoluble in water due to its hydrophobic nature. Chemically, N-Cyclohexylaniline is weakly basic and stable under standard conditions. It does not react violently with water or common acids but should be stored away from strong oxidizers to prevent hazardous reactions. Its stability and solubility profile make it a versatile intermediate in organic synthesis.

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Main Applications

N-Cyclohexylaniline is widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. In the pharmaceutical industry, it serves as a building block for active pharmaceutical ingredients (APIs) and other drug compounds. Its role in agrochemicals includes the production of herbicides and pesticides. Additionally, N-Cyclohexylaniline finds applications in the manufacture of dyes, rubber chemicals, and corrosion inhibitors. Its versatility as a chemical intermediate stems from its ability to undergo various reactions, including alkylation, acylation, and condensation, making it valuable in multiple industrial processes.

Safety and Storage

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N-Cyclohexylaniline should be handled with care to avoid exposure. It can cause irritation to the skin, eyes, and respiratory system upon contact or inhalation. Proper personal protective equipment (PPE), such as gloves, goggles, and respiratory masks, should be worn when handling this compound. Storage conditions are critical to maintaining the stability of N-Cyclohexylaniline. It should be stored in a cool, dry, well-ventilated area, away from oxidizers and strong acids. Containers should be tightly sealed to prevent moisture ingress and contamination. Spills should be contained and cleaned up immediately using appropriate absorbent materials.

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B2B Procurement Guide

When procuring N-Cyclohexylaniline, B2B buyers should prioritize suppliers with a proven track record of quality and reliability. Key factors to consider include the compound's purity, which should be verified through certificates of analysis (CoA) and batch testing reports. Suppliers should also provide material safety data sheets (MSDS) for compliance with safety regulations. Pricing can vary based on purity, volume, and supplier location. Buyers should request samples for testing before large-scale purchases and negotiate contracts that include delivery timelines and quality guarantees. Establishing long-term relationships with reputable suppliers can ensure consistent quality and competitive pricing.

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