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N-Acetylmorpholine

Updated: 2026-07-19

Overview

N-Acetylmorpholine is an organic compound derived from morpholine with an acetyl group substitution. It serves as a valuable solvent and intermediate in various chemical processes. The compound is particularly valued for its high boiling point and ability to dissolve a wide range of substances. In industrial applications, it's commonly used as a reaction medium and as a building block in pharmaceutical synthesis.

Physical and Chemical Properties

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As a polar aprotic solvent, N-Acetylmorpholine exhibits excellent solvation properties for many organic compounds and some polymers. Its physical characteristics include a moderate viscosity and a faint amine-like odor. The chemical stability of N-Acetylmorpholine makes it suitable for high-temperature applications. It's relatively non-volatile compared to similar solvents, which contributes to its safety profile in industrial settings.

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Main Applications

The primary use of N-Acetylmorpholine is in pharmaceutical manufacturing, where it serves as an intermediate for various active pharmaceutical ingredients (APIs). Its solvent properties make it particularly useful in polymer processing and specialty chemical synthesis. Additional applications include its use as a catalyst in certain chemical reactions and as a component in some specialty cleaning formulations. The compound's versatility continues to find new applications in advanced material development.

Safety and Storage

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While N-Acetylmorpholine is not classified as highly hazardous, proper handling procedures should be followed. The compound can cause irritation to skin, eyes, and respiratory tract upon exposure. Storage should be in tightly sealed containers made of compatible materials (typically stainless steel or certain plastics). The product is stable under normal conditions but should be protected from extreme heat and direct sunlight to maintain quality.

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B2B Procurement Guide

When sourcing N-Acetylmorpholine, buyers should specify required purity levels, which typically range from 98% to 99.5% for most industrial applications. Packaging options vary from 200 kg drums to larger IBC containers for bulk purchases. Quality certifications such as ISO standards or specific pharmacopeia compliance may be required for certain applications. Lead times can vary depending on market conditions, so buyers should plan procurement accordingly.

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