Overview
MPE-PEG is a functionalized polyethylene glycol (PEG) derivative featuring a methoxy group at one end and a reactive epoxide group at the other. This bifunctional polymer is prized for its ability to conjugate with proteins, peptides, or nanoparticles while maintaining solubility and stealth properties in biological systems. Developed as a versatile linker in bioconjugation, MPE-PEG bridges hydrophobic drugs and hydrophilic carriers, enhancing pharmacokinetics. Its applications span from pharmaceutical formulations to advanced material coatings, driven by PEG's FDA-approved safety profile and tunable physicochemical properties.
Physical and Chemical Properties
MPE-PEG exhibits typical PEG characteristics including high water solubility, low viscosity in solution, and resistance to protein adsorption. The epoxide group enables nucleophilic reactions with amines, thiols, or hydroxyls under mild conditions, forming stable covalent bonds. Its molecular weight directly influences properties like hydrodynamic volume and degradation rate. Lower MW variants (350-1000 Da) are used for small molecule conjugation, while higher MW (2000-5000 Da) versions prolong circulation half-life in drug delivery. Thermal stability is moderate, with decomposition occurring above 200°C.
Main Applications
In pharmaceuticals, MPE-PEG modifies therapeutic proteins (PEGylation) to reduce immunogenicity and extend half-life. It's critical for stealth liposomes and nanoparticle drug carriers targeting tumors or inflammatory sites. Material scientists use it to create non-fouling surfaces on medical devices like catheters or implants. The epoxide group allows grafting onto silica, gold, or polymer matrices. Emerging applications include bioink formulations for 3D bioprinting and crosslinkable hydrogels for tissue engineering scaffolds.
Safety and Storage
While PEG derivatives are generally safe, MPE-PEG's epoxide group requires careful handling. Use nitrile gloves and dust masks to prevent inhalation of powder. Store under argon or nitrogen to prevent moisture absorption and epoxide ring opening. For long-term stability, aliquot into smaller amber vials with desiccants. Avoid contact with strong acids/bases that may hydrolyze the epoxide. Dispose following local regulations for non-hazardous polymers.
B2B Procurement Guide
Industrial buyers should verify certificates of analysis (CoA) for molecular weight distribution (PDI <1.2 preferred), epoxide content (>90%), and residual solvents. Bulk pharmaceutical-grade purchases require GMP compliance documentation. Leading manufacturers include Sigma-Aldrich (now MilliporeSigma), JenKem Technology, and NOF Corporation. Request batch-specific stability data for critical applications. For nanoparticle coatings, opt for ultra-high purity grades to minimize aggregation risks.
Related Manufacturers
- 主营：特殊peg
- 主营：单分散peg、聚乙二醇、马来酰亚胺