Overview
Mouse P-selectin is a transmembrane glycoprotein belonging to the selectin family, primarily expressed on activated endothelial cells and platelets. It plays a pivotal role in the inflammatory response by facilitating the adhesion of leukocytes to blood vessel walls. This molecule is crucial for studies in immunology, thrombosis, and vascular biology. As a research tool, Mouse P-selectin is widely used to investigate leukocyte trafficking, inflammation mechanisms, and potential therapeutic targets. Its recombinant forms are often produced for experimental use, ensuring consistency and reproducibility in scientific studies.
Physical and Chemical Properties
Mouse P-selectin is a glycoprotein with a molecular weight of approximately 140 kDa. It consists of an N-terminal lectin domain, an epidermal growth factor (EGF)-like domain, multiple short consensus repeats (SCRs), a transmembrane domain, and a cytoplasmic tail. The protein is typically supplied as a lyophilized powder or in liquid buffer solutions. Its solubility depends on the formulation, but it generally dissolves well in standard aqueous buffers like PBS or Tris-HCl. The protein's stability is influenced by storage conditions, with recommended storage at -20°C or lower to maintain biological activity over time.
Main Applications
In biomedical research, Mouse P-selectin is primarily used to study inflammatory processes, leukocyte recruitment, and vascular biology. Researchers employ it in in vitro adhesion assays, flow chamber experiments, and animal models of inflammation. It's also valuable for developing anti-inflammatory drugs that target selectin-mediated pathways. The protein serves as a critical reagent in thrombosis research, as P-selectin mediates platelet-leukocyte interactions. Additionally, it's used in immunological studies to understand leukocyte rolling and extravasation mechanisms, providing insights into autoimmune diseases and infection responses.
Safety and Storage
Mouse P-selectin should be handled following standard laboratory safety protocols for biological reagents. Use personal protective equipment, including gloves and lab coats, to prevent skin contact or inhalation of particulates. In case of accidental exposure, wash thoroughly with water and seek medical advice if irritation persists. For long-term storage, keep the protein at -20°C or lower in aliquots to avoid repeated freeze-thaw cycles that may degrade the molecule. Lyophilized forms are generally stable for years when stored properly, while reconstituted solutions should be used within weeks and kept at 4°C during short-term use.
B2B Procurement Guide
When procuring Mouse P-selectin for research or industrial applications, prioritize suppliers with proven track records in recombinant protein production. Key considerations include certificate of analysis (CoA) details such as purity (>90% by SDS-PAGE), endotoxin levels (<1 EU/μg), and functional activity verified by binding assays. For large-scale orders, inquire about bulk discounts and custom formulation options. Compare lead times among vendors, as some may offer expedited production for urgent requirements. Consider requesting samples for preliminary testing before committing to substantial purchases, especially for novel applications.
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