Overview
Mouse Oxytocin is a conserved neuropeptide hormone with a cyclic structure formed by a disulfide bridge between two cysteine residues. It shares 90% sequence homology with human oxytocin, differing by only one amino acid. This peptide plays critical roles in social cognition, maternal behavior, and stress modulation in rodents. As a research chemical, it is widely used to study the neurobiological mechanisms of social bonding and anxiety-related behaviors. The commercial product is typically synthesized via solid-phase peptide synthesis (SPPS) and purified to >95% for experimental use.
Physical and Chemical Properties
Mouse Oxytocin is a white, lyophilized powder with high stability when stored properly. The cyclic nonapeptide structure (CYIQNCPLG-NH2) confers resistance to enzymatic degradation compared to linear peptides. Its solubility in aqueous solutions varies with pH, showing optimal stability in slightly acidic buffers (pH 4-6). The peptide exhibits UV absorption at 280 nm due to tyrosine residues. Mass spectrometry and HPLC are standard methods for purity verification. Unlike human oxytocin, the mouse variant has an isoleucine substitution at position 3, which may affect receptor-binding kinetics in cross-species studies.
Main Applications
In preclinical research, mouse oxytocin is primarily administered via intranasal, intracerebroventricular (ICV), or intraperitoneal routes to investigate its effects on social recognition, pair bonding, and anxiety-like behaviors in rodent models. It serves as a key tool in autism spectrum disorder (ASD) and schizophrenia research. Pharmaceutical companies use it as a reference standard for developing oxytocin receptor agonists/antagonists. Recent applications include studying its role in wound healing and gastrointestinal motility. When compared to arginine vasopressin (AVP), mouse oxytocin shows higher selectivity for OXTR receptors.
Safety and Storage
As a bioactive peptide, mouse oxytocin requires careful handling. Use nitrile gloves and safety goggles to prevent accidental exposure. Avoid inhalation of powder during reconstitution—work in a fume hood for large quantities. Spills should be neutralized with dilute acetic acid. For long-term storage, lyophilized powder remains stable for 2-3 years at -20°C in sealed vials with desiccant. Reconstituted solutions in PBS (pH 7.4) retain activity for 1-2 weeks at 4°C or 3-6 months when aliquoted at -80°C. Repeated freeze-thaw cycles degrade peptide integrity.
B2B Procurement Guide
Research-grade mouse oxytocin is typically sold in 0.1mg to 10mg quantities. Key procurement considerations include: 1) Certificate of Analysis (CoA) with HPLC purity data, 2) mass spectrometry confirmation, 3) endotoxin testing for in vivo studies, and 4) batch-to-batch consistency guarantees. Leading suppliers include Sigma-Aldrich, Tocris, and peptide specialty manufacturers. Bulk orders (100mg+) may qualify for 15-30% discounts. For GMP-grade material (required for clinical trials), expect 5-10x higher pricing due to additional quality controls. Always verify shipping conditions—lyophilized peptides require cold chain transport for tropical regions.
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