Overview
The Mouse α2-Adrenoceptor (α2-AR) is a member of the adrenergic receptor family, which mediates the effects of catecholamines like norepinephrine and epinephrine. It is predominantly found in the central and peripheral nervous systems, where it regulates various physiological responses, including blood pressure, sedation, and pain perception. The receptor is a target for numerous pharmacological agents, making it a critical subject in drug development and neuroscience research. Structurally, the Mouse α2-AR is a G protein-coupled receptor (GPCR) with seven transmembrane domains. It exists in three subtypes (α2A, α2B, and α2C), each with distinct tissue distributions and functional roles. Researchers often study these subtypes to understand their specific contributions to physiological and pathological processes.
Physical and Chemical Properties
The Mouse α2-Adrenoceptor is a protein with no defined molecular formula or weight due to its complex structure. It is typically isolated or expressed in cell lines and solubilized in buffers containing detergents for experimental use. The receptor's activity is highly dependent on its conformational state, which is influenced by ligand binding and post-translational modifications. In terms of solubility, the receptor is stable in aqueous solutions with mild detergents like Triton X-100 or CHAPS. Storage conditions are critical to maintaining its functionality; prolonged exposure to room temperature or repeated freeze-thaw cycles can degrade the protein. For long-term preservation, aliquoting and storage at -80°C are recommended.
Main Applications
The Mouse α2-Adrenoceptor is extensively used in pharmacological and neurological research. It serves as a model system for studying GPCR signaling mechanisms and the effects of adrenergic agonists and antagonists. Researchers employ it to investigate conditions like hypertension, anxiety, and pain, where adrenergic signaling is dysregulated. In drug discovery, the receptor is a target for developing antihypertensive, sedative, and analgesic agents. Compounds like clonidine and dexmedetomidine, which selectively activate α2-AR, are clinically used for their hypotensive and sedative properties. Additionally, the receptor is utilized in high-throughput screening assays to identify novel modulators with therapeutic potential.
Safety and Storage
Handling the Mouse α2-Adrenoceptor requires standard laboratory safety protocols. While the protein itself is not highly hazardous, precautions should be taken to avoid contamination and degradation. Use personal protective equipment (PPE) such as gloves and lab coats when working with the receptor or its solutions. Storage is a critical factor in maintaining the receptor's stability. Aliquots should be stored at -20°C for short-term use or -80°C for long-term preservation. Avoid repeated freeze-thaw cycles, as they can denature the protein. Always label containers clearly with the date of preparation and concentration to ensure proper usage.
B2B Procurement Guide
When procuring the Mouse α2-Adrenoceptor, prioritize suppliers with a proven track record in protein production and characterization. Key considerations include the receptor's purity (verified by SDS-PAGE or HPLC), activity (assessed by binding or functional assays), and source (recombinant or native). Pricing varies depending on the quantity and formulation (e.g., lyophilized or in solution). Bulk purchases may offer cost savings, but ensure the supplier can meet your specific requirements. Always request certificates of analysis (CoA) and ensure compliance with your institution's procurement policies. For research applications, consider custom services like receptor tagging or pre-coupled G proteins for specialized experiments.
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