Overview
5-Methylthiazole is a heterocyclic organic compound belonging to the thiazole family. It is characterized by a five-membered ring containing nitrogen and sulfur atoms, with a methyl group attached at the fifth position. This compound is primarily used as an intermediate in the synthesis of more complex molecules, particularly in pharmaceuticals and agrochemicals. Due to its unique chemical structure, 5-Methylthiazole serves as a building block for various active ingredients. Its applications extend to the flavor and fragrance industry, where it contributes to the formulation of certain aroma compounds. The compound's volatility and distinct odor make it easily identifiable in laboratory settings.
Physical and Chemical Properties
5-Methylthiazole is a colorless to pale yellow liquid at room temperature with a density of approximately 1.07 g/cm³. It has a boiling point range of 135-137°C, making it relatively volatile compared to many other organic compounds. The molecular weight is 99.15 g/mol, with the formula C4H5NS. The compound exhibits moderate solubility in water but dissolves readily in common organic solvents such as ethanol, ether, and acetone. Its characteristic thiazole odor is noticeable even at low concentrations. As a flammable liquid, it requires careful handling to prevent ignition sources in the working environment.
Main Applications
The primary application of 5-Methylthiazole is as an intermediate in pharmaceutical synthesis. It serves as a key building block for various drugs, particularly those targeting neurological and anti-infective applications. In the agrochemical sector, it's used in the production of certain pesticides and herbicides. In the flavor and fragrance industry, 5-Methylthiazole contributes to creating specific roasted or nutty aroma profiles. Its derivatives are found in food flavorings and perfumes. Research applications include its use as a ligand in coordination chemistry and as a precursor in material science for creating specialized polymers.
Safety and Storage
5-Methylthiazole is classified as a flammable liquid and requires proper safety precautions during handling and storage. It should be kept in tightly sealed containers in a cool, well-ventilated area away from heat sources and open flames. Storage temperatures should not exceed 25°C for optimal stability. Personal protective equipment including chemical-resistant gloves, safety goggles, and proper ventilation should be used when working with this compound. In case of spillage, absorb with inert material and dispose of according to local regulations. Fire extinguishing should be done using dry chemical powder, foam, or carbon dioxide - never use water jets.
B2B Procurement Guide
When procuring 5-Methylthiazole, verify the CAS number (3581-91-7) to ensure product authenticity. Request certificates of analysis specifying purity levels, which typically range from 95% to 99% for industrial applications. Pharmaceutical-grade material may require higher purity standards. Consider ordering in appropriate quantities based on your usage needs, as storage stability can be a concern. Price negotiations are possible for bulk orders exceeding 100kg. Always ensure suppliers provide proper Safety Data Sheets (SDS) and comply with transportation regulations for hazardous chemicals. Lead times may vary depending on supplier inventory and production schedules.
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