Overview
Methylglucamine (N-Methyl-D-glucamine) is an organic compound derived from glucose and methylamine. It is widely recognized for its versatility in pharmaceutical and chemical applications. The compound serves as a crucial intermediate in drug synthesis and finds particular use in contrast media for medical imaging. As a chiral building block, methylglucamine offers unique stereochemical properties that make it valuable in asymmetric synthesis. Its water solubility and chelating abilities further expand its utility in various industrial processes.
Physical and Chemical Properties
Methylglucamine appears as a white crystalline powder with a melting point between 128-131°C. It demonstrates excellent solubility in water and moderate solubility in polar organic solvents. The compound's molecular structure contains multiple hydroxyl groups, contributing to its hydrophilic nature and chelating capabilities. Chemically, methylglucamine is stable under normal conditions but should be protected from extreme temperatures and moisture. Its chiral center at the glucose moiety makes it particularly useful for stereospecific reactions in pharmaceutical synthesis.
Main Applications
The primary application of methylglucamine is in the pharmaceutical industry, where it serves as a key intermediate in contrast agents for radiographic imaging. It forms stable complexes with various metals, making it ideal for iodine-based contrast media used in X-ray procedures. Beyond medical applications, methylglucamine finds use as a chiral auxiliary in organic synthesis, particularly for resolving racemic mixtures. Its chelating properties also make it valuable in metal ion sequestration and as a component in certain cleaning formulations.
Safety and Storage
Methylglucamine is generally considered safe with low toxicity, but standard laboratory precautions should be observed. Avoid inhalation of dust particles and direct contact with eyes. In case of exposure, rinse thoroughly with water. For optimal storage, keep the compound in its original tightly sealed container at room temperature, protected from moisture and direct sunlight. Under proper conditions, methylglucamine maintains stability for several years without significant degradation.
B2B Procurement Guide
When procuring methylglucamine for industrial use, verify the supplier's certifications and quality control processes. Pharmaceutical-grade material should meet USP or EP standards if intended for medical applications. Key specifications to confirm include purity level (typically 98-99.5%), heavy metal content, and residual solvent levels. Bulk purchases may offer cost advantages, but consider storage capacity and shelf life. For reference, current market prices range approximately $50-150 per kilogram depending on quantity and purity requirements. Always request material safety data sheets (MSDS) and certificates of analysis before purchase.
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