Methylacetophenone
Overview
Methylacetophenone is an aromatic ketone with the chemical formula C9H10O. It is commonly referred to as 4'-Methylacetophenone due to the methyl group positioned at the para site of the benzene ring. The compound is a colorless to pale yellow liquid with a characteristic sweet, floral odor, making it a popular choice in the fragrance industry. As a versatile intermediate, Methylacetophenone is utilized in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its stability and reactivity under controlled conditions ensure broad applicability in organic synthesis and industrial processes.
Physical and Chemical Properties
Methylacetophenone exhibits a density of 1.005 g/cm³ at 20°C and a boiling point of 226°C. It remains stable under standard conditions but may decompose at high temperatures, releasing carbon monoxide and other hazardous gases. The compound is soluble in common organic solvents like ethanol and ether but has limited solubility in water. Key chemical properties include its reactivity as a ketone, participating in condensation and reduction reactions. Its aromatic ring structure contributes to its stability and suitability for electrophilic substitution reactions, often used in the production of derivatives for fragrances and pharmaceuticals.
Main Applications
In the fragrance industry, Methylacetophenone is prized for its sweet, floral scent, often incorporated into perfumes, soaps, and cosmetic formulations. It serves as a fixative, enhancing the longevity of fragrances. The pharmaceutical sector employs Methylacetophenone as an intermediate in synthesizing active pharmaceutical ingredients (APIs). Its derivatives are explored for potential therapeutic properties, including anti-inflammatory and antimicrobial effects. Additionally, it is used in agrochemicals and as a solvent or reagent in laboratory settings.
Safety and Storage
Methylacetophenone is classified as an irritant, posing risks to skin, eyes, and respiratory systems upon exposure. Proper personal protective equipment (PPE), including gloves and goggles, is mandatory during handling. The compound is flammable, requiring storage away from heat and open flames. Recommended storage conditions include a cool, dry, and well-ventilated area in tightly sealed containers. Incompatible materials include strong oxidizing agents. Spills should be contained using inert absorbents and disposed of following local regulations.
B2B Procurement Guide
When procuring Methylacetophenone, prioritize suppliers with certifications such as ISO 9001 or GMP compliance, especially for pharmaceutical-grade material. Key specifications to verify include purity (typically ≥98%), CAS number (122-00-9), and absence of contaminants. Bulk purchases may offer cost advantages, but ensure proper storage capacity to maintain product integrity. Request Safety Data Sheets (SDS) and conduct audits if sourcing from new vendors. Market prices fluctuate based on raw material costs and demand, with reference ranges of $50-$150/kg.
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