Overview
Methyl α-D-Glucuronate is a derivative of glucuronic acid, commonly used in biochemical and pharmaceutical research. It serves as a key intermediate in the synthesis of glycosides and other complex carbohydrates. The compound is valued for its role in studying enzymatic processes and metabolic pathways. Its structural similarity to natural glucuronides makes it a useful tool in drug development and glycobiology. Researchers often employ it to investigate glycosylation mechanisms, which are critical in cell signaling and immune responses.
Physical and Chemical Properties
Methyl α-D-Glucuronate appears as a white to off-white crystalline powder with a molecular weight of 208.17 g/mol. It is soluble in water and polar organic solvents, making it versatile for laboratory applications. The compound has a melting point range of 150-155°C, indicating moderate thermal stability. Its hygroscopic nature requires careful storage to prevent moisture absorption, which can affect purity and performance. The molecular formula C7H12O7 reflects its carbohydrate-derived structure, featuring both ester and hydroxyl functional groups.
Main Applications
This compound is primarily used in pharmaceutical research as an intermediate for synthesizing glycosylated drugs. It plays a significant role in studying glucuronidation, a detoxification process in the liver. Additionally, it is utilized in biochemical assays to understand carbohydrate metabolism. In industrial settings, Methyl α-D-Glucuronate may be employed in the production of specialty chemicals and diagnostic reagents. Its compatibility with enzymatic reactions makes it valuable for biotechnology applications, including enzyme inhibition studies.
Safety and Storage
Proper handling of Methyl α-D-Glucuronate requires adherence to safety protocols. Avoid direct contact with skin, eyes, or respiratory system. Use gloves, goggles, and lab coats when working with this chemical. In case of exposure, rinse affected areas immediately with water. Store the compound in a tightly sealed container in a cool, dry place, away from light and moisture. Long-term storage under inert gas may enhance stability. Dispose of unused material according to local regulations for organic waste.
B2B Procurement Guide
When procuring Methyl α-D-Glucuronate, verify the supplier's certification and product specifications. Request certificates of analysis (CoA) to confirm purity, typically ≥95% for research-grade material. Bulk purchases (100g or more) may qualify for discounted pricing. Consider lead times and shipping conditions, as some suppliers may require temperature-controlled transport. Establish a relationship with reputable chemical distributors to ensure consistent quality and availability. For specialized applications, custom synthesis options may be available.
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