Overview
Methyl chlorocinnamate is an organic compound belonging to the class of cinnamate esters. It is derived from cinnamic acid and features a chlorine substituent on the phenyl ring, enhancing its reactivity in synthetic applications. Primarily used in the pharmaceutical and fragrance industries, this compound serves as a versatile intermediate. Its synthesis typically involves esterification of chlorocinnamic acid with methanol under controlled conditions.
Physical and Chemical Properties
Methyl chlorocinnamate is characterized by its white crystalline appearance and distinct aromatic odor. It exhibits moderate solubility in polar organic solvents but limited solubility in water, making it suitable for organic-phase reactions. The presence of the chlorine atom increases its electrophilic reactivity, facilitating its use in cross-coupling reactions and other transformations. Its melting point ranges between 70-75°C, and it remains stable under standard storage conditions.
Main Applications
In pharmaceuticals, methyl chlorocinnamate is employed as a building block for active pharmaceutical ingredients (APIs), particularly in anti-inflammatory and antimicrobial agents. Its structural features allow for further functionalization. The compound also finds use in perfumery, where it contributes to woody or balsamic notes. Additionally, researchers utilize it in organic synthesis to develop novel compounds with tailored properties.
Safety and Storage
Handling methyl chlorocinnamate requires standard laboratory precautions, including gloves and eye protection. Prolonged exposure to dust or vapors should be avoided to prevent respiratory or skin irritation. Storage recommendations include keeping the material in tightly sealed containers under inert conditions. Compatibility with common construction materials like HDPE and glass ensures safe long-term storage.
B2B Procurement Guide
When sourcing methyl chlorocinnamate, buyers should prioritize suppliers with certified quality control processes, especially for pharmaceutical-grade material. Key specifications to verify include purity (typically 98-99%), residual solvent levels, and heavy metal content. Bulk procurement may offer cost advantages, but buyers should assess storage capabilities and shelf-life considerations. Establishing long-term contracts with reliable manufacturers can ensure consistent supply and favorable pricing.
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