Methyl 4-hydroxy-2-pyridinecarboxylate
Overview
Methyl 4-hydroxy-2-pyridinecarboxylate is a chemical compound primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its molecular structure features a pyridine ring with a hydroxyl group and a methyl ester, making it a versatile building block in organic chemistry. The compound is synthesized through esterification reactions and is valued for its stability and reactivity in further chemical transformations. Its applications span various industries, particularly in the development of active pharmaceutical ingredients (APIs) and crop protection agents.
Physical and Chemical Properties
Methyl 4-hydroxy-2-pyridinecarboxylate typically appears as a white to off-white crystalline powder with a molecular weight of 153.14 g/mol. It has a melting point range of approximately 150-155°C, indicating its stability under moderate temperatures. The compound is soluble in common organic solvents such as methanol and ethanol but exhibits limited solubility in water. This property makes it suitable for use in organic synthesis where polar solvents are employed. Its stability under normal storage conditions ensures a reasonable shelf life when handled properly.
Main Applications
The primary use of Methyl 4-hydroxy-2-pyridinecarboxylate is as an intermediate in the pharmaceutical industry. It serves as a key building block in the synthesis of various APIs, including antiviral and antibacterial agents. In the agrochemical sector, the compound is utilized in the production of pesticides and herbicides. Its reactive sites allow for further functionalization, enabling the development of targeted crop protection solutions. Additionally, it finds niche applications in research and development for novel chemical entities.
Safety and Storage
Methyl 4-hydroxy-2-pyridinecarboxylate should be handled with care, using appropriate PPE such as gloves, goggles, and lab coats. Avoid inhalation and direct skin contact, as it may cause irritation. For storage, keep the compound in a cool, dry place away from direct sunlight and moisture. Use airtight containers to prevent degradation. In case of accidental exposure, follow standard first aid procedures and consult a medical professional if necessary.
B2B Procurement Guide
When procuring Methyl 4-hydroxy-2-pyridinecarboxylate, prioritize suppliers with verified credentials and a track record of reliability. Request certificates of analysis (CoA) to confirm purity levels, which typically range from 95% to 99%. Consider bulk purchasing for cost efficiency, but ensure proper storage facilities are available. Pricing varies based on quantity and purity, with reference ranges approximately $50-$100 per gram. Always review the Material Safety Data Sheet (MSDS) for handling and safety guidelines.
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