Overview
Methyl 2-amino-5-iodobenzoate is an organic compound belonging to the class of iodinated benzoates. It is widely utilized as a building block in the synthesis of complex molecules, particularly in pharmaceutical research. The compound's structure features an amino group and an iodine atom, which make it a versatile intermediate for further chemical modifications. Its primary role in industrial applications is as a precursor in the production of active pharmaceutical ingredients (APIs). The iodine atom in the molecule allows for further functionalization, making it valuable in medicinal chemistry. The compound is typically supplied as a crystalline powder with moderate stability under proper storage conditions.
Physical and Chemical Properties
Methyl 2-amino-5-iodobenzoate exhibits distinct physical and chemical properties that determine its applications. It appears as an off-white to light yellow crystalline powder with a melting point of approximately 120-125°C. The compound is soluble in common organic solvents like ethanol and dimethyl sulfoxide (DMSO), but its solubility in water is limited. Chemically, the presence of the iodine atom makes it susceptible to light-induced degradation, necessitating storage in opaque containers. The amino group provides a reactive site for further chemical transformations, such as acylation or alkylation. Stability under normal conditions is moderate, but exposure to moisture or extreme temperatures should be avoided to prevent decomposition.
Main Applications
The primary use of methyl 2-amino-5-iodobenzoate is in pharmaceutical synthesis, where it serves as an intermediate for the preparation of more complex molecules. Its iodine moiety allows for cross-coupling reactions, which are pivotal in constructing pharmacologically active compounds. Additionally, it finds applications in organic chemistry research, particularly in the development of novel heterocyclic compounds. The compound's versatility makes it a valuable tool for medicinal chemists aiming to explore new drug candidates. Some specialized applications include its use in radiopharmaceuticals and as a labeling agent in molecular imaging.
Safety and Storage
Handling methyl 2-amino-5-iodobenzoate requires adherence to safety protocols to minimize health risks. The compound should be stored in a cool, dry environment, protected from light and moisture. Containers must be tightly sealed to prevent contamination or degradation. Personal protective equipment (PPE), including gloves, goggles, and lab coats, is essential when working with this chemical. Inhalation or skin contact should be avoided, and operations should be conducted in a fume hood to ensure adequate ventilation. In case of exposure, immediate washing with water and medical consultation are recommended.
B2B Procurement Guide
When procuring methyl 2-amino-5-iodobenzoate, B2B buyers should prioritize quality and supplier reliability. Key considerations include verifying the CAS number, purity specifications, and compliance with safety standards. Requesting certificates of analysis (CoA) from suppliers is advisable to ensure product quality. Prices vary based on purity and order volume, with bulk purchases often attracting discounts. Lead times and shipping conditions should be confirmed, as the compound may require special handling. Establishing long-term relationships with reputable suppliers can ensure consistent quality and availability.
Related Manufacturers
- 主营：有机原料、中间体、香精香料、催化剂、有机硅、表面活性剂
- 主营：4-D钠盐、N-甲基硫脲、N-甲基吡咯烷酮、N-甲基邻氨基苯甲酸甲酯、菜籽油甲酯、单辛酸甘油酯、三硫代碳酸钠、辛酸镁盐、8-辛二醇、羟丙基纤维素、硫酸烟酰苯胺、离子液体、咪唑、表面活性剂、光引发剂、紫外线吸收剂、UV单体
- 主营：磺酰胺、氧化铌、除醛剂、25kg、硅化镱、基硅油、成核剂、酞菁钴、甘氨酸铬、光学树脂、鼠李糖脂、甲磺酸铋、氧化亚铁、封端硅油、左旋乳酸)、六水氯化钇、己基磺酸盐、恩诺沙星钠、二聚季戊四醇、聚醚硫酸酯钠、恶唑啉交联剂、洗手凝胶增稠剂、生物活性玻璃粉、氰基丙烯酸乙酯、脱硫脱氢催化剂
- 主营：甘氨酸、甘氨酰、胰酵素、蒽甲酯、喹烯酮、黄蒿油、十五醛、碳酸镧、酰氨酸、芹菜酮、赖氨酸、980卡波、香气醇、百部酮、海蓝腈、高哌嗪、氯戊烷、苯二甲、姜黄素、三氮唑、雌三醇、溴氯苯、橙花素、纯吲哚、抗氧剂
- 主营：甘氨酸、溴化物、戊酸鈉、蒽甲酸、联吡啶、紫苏葶、锂电池、牛磺酸、褪黑素、磷酸铟、新癸酸、赖氨酸、溴化鏻、乙氧基、藏花醛、豆甾醇、羟乙基、维素酶、庚二酸、呋虫胺、丹参素、萘甲醛、槐豆胶、黄柏酮、元明粉
- 主营：17746-77-9、三癸基铝、甲氧苯基、625392-06-5、1423716-55-5、1547041-34-8、甲氧基苯甲酸、磺胺曲沙唑、8-二羟基萘、三十二烷基铝、4-氯嘧啶盐酸盐
- 主营：正辛胺、柠檬酸、尿嘧啶、15397-15-6、119736-16-2、923289-21-8、152628-02-9、氨基二环、2346620-55-9、抗皱素、绿原酸、异丁基、三辛胺、双醚芴、姜黄素、角鲨烯、精磺胺、蒜氨酸、九甘醇、氟苯基、4-嘧啶酮、苯甲酰胺、比卡鲁胺、四氢嘧啶、麦角硫因
- 主营：苯肼、氯甲基苯乙烯、无水氯化锂、丙酰乙酸甲酯、碘甲烷、邻硝基苯磺酰氯、亚磷酸三苯酯、4-二氢吡喃、苯并噻唑、苄胺、4-溴靛红、苯基锂、叔丁醇钾、三丁基膦、四羟基二硼
- 主营：吡啶盐酸盐