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Methoxyacetophenone

Updated: 2026-07-15

Overview

Methoxyacetophenone is an aromatic ketone with a distinctive floral scent, commonly used in perfumery and pharmaceuticals. It is derived from acetophenone through methoxylation and is valued for its stability and pleasant odor. The compound is also utilized as an intermediate in organic synthesis and as a UV stabilizer in certain applications. Its production involves controlled chemical reactions to ensure high purity, making it suitable for sensitive applications like fragrances and drug formulations. Methoxyacetophenone is often preferred over similar compounds due to its balanced odor profile and chemical stability.

Physical and Chemical Properties

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Methoxyacetophenone appears as a white to pale yellow crystalline solid with a melting point of 36-38 °C and a boiling point of 258 °C. It has a density of 1.08 g/cm³ and is soluble in organic solvents like ethanol and ether but only slightly soluble in water. The compound is stable under normal conditions but may degrade when exposed to strong oxidizing agents. Its key chemical property is the presence of a methoxy group attached to the benzene ring, which enhances its solubility in organic solvents and contributes to its floral aroma. The compound’s stability and solubility make it versatile for various industrial applications.

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Main Applications

Methoxyacetophenone is primarily used in the fragrance industry as a floral note in perfumes and scented products. Its pleasant odor profile makes it a popular choice for creating complex fragrance blends. In the pharmaceutical sector, it serves as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). Additionally, the compound is employed as a flavoring agent in food products and as a UV stabilizer in plastics and coatings. Its ability to absorb UV light makes it useful in protecting materials from degradation caused by sunlight exposure. These diverse applications highlight its importance in multiple industries.

Safety and Storage

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Methoxyacetophenone should be handled with care to avoid skin and eye irritation. Personal protective equipment (PPE), including gloves and goggles, is recommended when working with the compound. In case of contact, rinse thoroughly with water and seek medical attention if irritation persists. Storage conditions should include a cool, dry, and well-ventilated area, away from heat sources and open flames. The compound should be kept in tightly sealed containers to prevent contamination and degradation. Proper disposal methods should be followed to minimize environmental impact.

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B2B Procurement Guide

When procuring methoxyacetophenone, verify the CAS number (100-06-1) and purity specifications to ensure quality. Reputable suppliers should provide certificates of analysis (CoA) and material safety data sheets (MSDS). Bulk purchases often qualify for discounts, so consider ordering larger quantities if the application permits. Evaluate supplier reliability, lead times, and shipping conditions to avoid delays or quality issues. It’s also advisable to test samples before committing to large orders to confirm the product meets your requirements. Transparency in pricing and terms is essential for a smooth procurement process.

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