Methoxy PEG alkyne

Updated: 2026-07-21

Overview

Methoxy PEG Propargyl is a functionalized polyethylene glycol (PEG) derivative featuring a terminal propargyl group (-C≡CH) and a methoxy end (-OCH3). This bifunctional molecule is pivotal in bioconjugation and pharmaceutical research due to its compatibility with click chemistry, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC). The PEG backbone ensures water solubility and reduces immunogenicity, making it ideal for modifying peptides, proteins, and nanoparticles. Its modular design allows customization of PEG chain lengths (e.g., 350–20,000 Da) to tailor hydrodynamic size and steric effects. The propargyl group reacts selectively with azides, enabling site-specific labeling or crosslinking without interfering with biological activity. This compound is widely adopted in drug delivery systems, diagnostics, and biomaterial coatings.

Physical and Chemical Properties

Methoxy PEG Propargyl exhibits typical PEG characteristics, including high hydrophilicity, low toxicity, and tunable molecular weights. The propargyl terminus is stable under ambient conditions but reacts efficiently with azides in the presence of copper catalysts. Its solubility profile allows use in aqueous and organic solvents, though prolonged exposure to light or oxidants may degrade the alkyne group. The compound’s melting point and viscosity depend on PEG chain length; shorter chains (<1,000 Da) often appear as liquids, while longer chains form waxy solids. Density ranges from 1.1–1.2 g/cm³, and it decomposes upon heating rather than boiling. NMR and FTIR are standard methods to confirm propargyl functionality and PEG integrity.

Main Applications

In bioconjugation, Methoxy PEG Propargyl links biomolecules (e.g., antibodies, enzymes) to fluorescent dyes, drugs, or surfaces via click chemistry. It enhances pharmacokinetics by prolonging circulation half-life of therapeutics, a strategy employed in PEGylated drugs like Adynovate®. Material science utilizes it to modify surfaces (e.g., gold nanoparticles, hydrogels) for biosensing or antifouling coatings. Its non-immunogenic PEG backbone is critical for in vivo applications, while the propargyl group enables modular functionalization. Emerging uses include CRISPR carrier systems and targeted cancer therapies, where precise biomolecule attachment is paramount.

Safety and Storage

While Methoxy PEG Propargyl is generally low-risk, precautions include avoiding inhalation of powders and direct skin contact. Use gloves and goggles in lab settings. The propargyl group is non-explosive but may react violently with strong oxidizers; store away from peroxides. Long-term stability requires storage at -20°C under argon or nitrogen to prevent moisture absorption and alkyne oxidation. Lyophilized powders are more stable than solutions, which may hydrolyze over time. Always verify functionality via FTIR or reactivity tests before use in critical applications.

B2B Procurement Guide

Procure from suppliers specializing in PEG derivatives, ensuring certificates of analysis (CoA) detail PEG length, polydispersity index (<1.05), and propargyl content (>95%). Bulk orders (1 kg+) may reduce costs by 20–30%. Key selection criteria include batch-to-batch consistency, endotoxin levels (<0.1 EU/mg for biomedical use), and solvent residues (e.g., <500 ppm DCM). For drug development, opt for GMP-grade material. Lead times vary; custom PEG lengths may require 4–8 weeks. Negotiate pricing tiers based on volume and purity requirements.