Overview
Meropenem is a carbapenem-class β-lactam antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria, including many multi-drug resistant strains. Developed in the 1980s, it represents an important tool in combating serious infections where other antibiotics fail. As a chemical reagent, meropenem is primarily used in pharmaceutical research and production. Its molecular structure contains the characteristic β-lactam ring that inhibits bacterial cell wall synthesis, making it valuable for studying antibiotic mechanisms and resistance patterns.
Physical and Chemical Properties
Meropenem appears as a white to off-white crystalline powder with good water solubility, which is critical for its pharmaceutical applications. The compound shows stability in aqueous solutions at room temperature for limited periods but degrades upon prolonged exposure to heat or light. The molecule contains both carboxyl and amino functional groups, giving it zwitterionic properties. Its stability is pH-dependent, with optimal stability observed in neutral to slightly alkaline conditions. The crystalline form is hygroscopic and requires careful moisture control during handling and storage.
Main Applications
In the pharmaceutical industry, meropenem serves as the active pharmaceutical ingredient (API) in injectable antibiotics used to treat complicated intra-abdominal infections, meningitis, and hospital-acquired pneumonia. Research applications include studies on antibiotic resistance mechanisms and β-lactamase inhibition. The reagent is also used in quality control laboratories for analytical method development and validation. Some institutions utilize meropenem in microbiological research to study its spectrum of activity against emerging resistant bacterial strains and for synergy testing with other antimicrobial agents.
Safety and Storage
As with many antibiotics, meropenem requires careful handling to prevent occupational exposure and environmental contamination. Use appropriate personal protective equipment including gloves, lab coat, and eye protection when handling the powder form. For long-term stability, store meropenem in its original packaging at 2-8°C, protected from light and moisture. The compound is sensitive to oxidation and should be kept under inert gas when possible. Opened containers should be used quickly and resealed tightly after each use to minimize degradation.
B2B Procurement Guide
When sourcing meropenem for research or pharmaceutical use, prioritize suppliers with proper certification and track record in antibiotic production. Key considerations include purity level (typically 98-99.5% for research use), sterility for pharmaceutical applications, and comprehensive analytical documentation. Request certificates of analysis (COA) that include HPLC purity, water content, residue on ignition, and microbial limits. For GMP applications, ensure the supplier can provide full regulatory support including DMF filings. Consider ordering smaller test quantities first to verify quality before committing to bulk purchases.
Related Manufacturers
- 主营：[]
- 主营：1689-89-0、酒石酸、61438-64-0、2美罗培南、81810-66-4、17316-67-5、31430-15-6、68786-66-3、42461-84-7、115550-35-1、217500-96-4、101831-37-2、129496-10-2、沃尼妙林、丹诺沙星、非泼罗尼、加米霉素、能霉素钠、达氟沙星、奥苯达唑、粘杆菌素、双氢链霉素、酸泰妙菌素、盐酸四咪唑、盐酸沙拉沙星
- 主营：清洗剂、缓蚀剂、聚合氯化铝、化学试剂、氟化氢铵、磷酸
- 主营：除垢剂、碘化钾、活性炭、碘试剂、基准试剂、化学试剂、氯化钠、丙三醇、缓冲剂、硫酸银、二甲亚砜、无水碳酸钠、食品添加剂、二甲基硅油、磷酸二氢钾、l(+)-抗坏血酸、无色透明液体、n-甲基吡咯烷酮
- 主营：磷酸氢、磷酸三钠
- 主营：无水乙醇、异丙醇、乙酸乙酯、石油醚
- 主营：铝酸钠、偏铝酸钠、中性氧化铝、分析试剂、药用层析氧化铝、活性氧化铝、丁基胶乳、丁基手套
- 主营：铝溶胶、硅溶胶、磷酸二氢铝、化学试剂氧化硼、油酸钠、油酸钾、十八胺、甲酸钠、硫酸氢钠、碳酸铵、尿素硝铵溶液、硝酸铵钙、碳酸亚铁、甲基硅酸、二氧化硫脲、氟硅酸镁、二羟甲基丙酸、葡萄糖酸钠、二甲基甲酰胺、四氯乙烯、正丁醇、大苏打、硝酸铁、油酸甲酯
- 主营：氧化铈、氧化镧、硝酸铈铵、高纯碳酸铈、硫酸高铈、硫酸铈、大粒径碳酸铈、低氯根碳酸铈、氢氧化铈
- 主营：液碱、片碱、纯碱、粒碱、氯化钙、柠檬酸、葡萄糖、小苏打、磷酸、聚合氯化铝、元明粉、氢氧化钙
- 主营：氧化铜
- 主营：溶剂油 D系列溶剂油、航空煤油取暖油燃料油、乙二醇二醋酸酯、化学试剂、乙二醇丁醚、聚甲氧基二甲醚、过氯乙烯树脂、高氯化聚乙烯、氯化橡胶、二乙二醇丁醚、亚硝酸钙、正丁醇、异丁醇、异丙醇、碳酸二甲酯、碳酸二乙酯、甲基丙烯酸甲酯、硫酸锆、硫酸锌、硝酸铝、硝酸铁、硝酸铜、一二三乙醇胺、苯酚、白油、乙酸乙酯、醋酸甲酯
- 主营：硫酸铜、二甲苯、均染剂、化学试剂、钼酸铵、液体肥、硫酸锌、乳化剂、锡酸钠、发黑液、叶面肥、混合菌、高碳醇、硫酸钴、络合剂、除油粉、糖醇锌、醋酸铜、氯化钾、壳寡糖、叔丁醇、清洗剂、糖醇硅、海藻硼、醋酸钴、防锈油
- 主营：次氯酸钠、氨水、涂料染料、工业级分析试剂、苯酚、乙醇、聚酯树脂、酒精、95乙醇、顺酐、苯酐、二甲基亚砜、氯化亚砜、工业红糖、漂白粉、乙二醇、戊二醛、苯并三氮唑、二甲基乙醇胺、甲醛阻聚剂、硫化铵、精对苯二甲酸、顺丁烯二酸酐、环己醇、二乙二醇丁醚
- 主营：乙酸钠、柠檬酸铵、甲酸铵、乙酸铵、草酸铵、草酸亚铁、硫酸亚铁、双乙酸钠、硫酸镁、碳酸钾、氯化钾、碳酸氢钾、甲酸钾、磷酸氢二钠、磷酸氢二钾
- 主营：聚合氯化铝、氯酸钠、片碱、纯碱、次氯酸钠、消泡剂、聚丙烯酰胺、聚合硫酸铁、液碱、氯化钾、小苏打、硫酸钡、元明粉、硫化钠、生石灰、葡萄糖、氨水、石灰