Overview
Meglumine is an organic compound derived from glucose and methylamine, primarily used in the pharmaceutical industry. As a sugar alcohol, it serves as a key excipient in iodinated contrast agents for radiographic procedures, helping to improve solubility and reduce toxicity. Pharmaceutical-grade meglumine meets strict purity standards set by pharmacopeias such as USP and EP. Its non-toxic nature and excellent water solubility make it ideal for parenteral formulations. The compound was first introduced in the mid-20th century and has since become essential in diagnostic medicine.
Physical and Chemical Properties
Meglumine appears as a white, odorless crystalline powder with a sweet taste. It demonstrates remarkable stability under normal storage conditions and shows no significant degradation when properly stored. The compound's high water solubility (freely soluble) is particularly valuable for injectable formulations. With a molecular weight of 195.21 g/mol, meglumine has a melting point range of 128-131°C. It's chemically stable in both acidic and basic conditions, though extreme pH values should be avoided. The substance is hygroscopic and should therefore be protected from moisture during storage.
Main Applications
The primary use of meglumine is in contrast media formulations, where it complexes with iodinated compounds to create water-soluble agents for X-ray and CT imaging. These include meglumine diatrizoate and meglumine ioxaglate, widely used in angiography and urography. Beyond radiology, meglumine serves as an alkalizing agent in pharmaceutical preparations and as a stabilizer in various drug formulations. Some antimony-based medications use meglumine as a counterion to improve solubility and bioavailability. The compound's applications continue to expand in specialized drug delivery systems.
Safety and Storage
Pharmaceutical-grade meglumine is generally considered safe when handled properly. Standard laboratory precautions should be followed: use personal protective equipment, avoid dust generation, and prevent contact with eyes and skin. Although low in toxicity, inhalation of powder should be avoided. For storage, maintain the product in its original tightly closed container at room temperature (15-30°C), protected from moisture and light. Under these conditions, meglumine typically has a shelf life of 3-5 years. Always check the manufacturer's expiration date and storage recommendations for specific products.
B2B Procurement Guide
When sourcing pharmaceutical-grade meglumine, prioritize suppliers with appropriate certifications (GMP, ISO) and who can provide detailed Certificates of Analysis. Key specifications to verify include purity (typically ≥98%), heavy metal content, and residual solvent levels. For large-volume procurement, consider contractual agreements that ensure consistent quality and supply. Price negotiations should account for purity grades, packaging options (bulk vs. pre-packaged), and transportation requirements. Many manufacturers offer technical support for formulation challenges, which can be valuable for specialized applications.
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