Overview
Medroxyprogesterone Acetate (MPA) is a synthetic derivative of progesterone, first developed in the 1950s. It mimics the effects of natural progesterone and is widely used in hormonal therapies. MPA is a key ingredient in contraceptives like Depo-Provera and is also utilized in treating hormone-sensitive conditions such as endometriosis and certain cancers. Its long-acting properties make it suitable for formulations requiring sustained release, such as injectable contraceptives. MPA is synthesized through chemical modification of progesterone, enhancing its stability and bioavailability compared to natural hormones.
Physical and Chemical Properties
MPA is a white or off-white crystalline powder with a molecular weight of 386.53 g/mol. It melts at 202-208°C and is soluble in organic solvents like acetone and chloroform but practically insoluble in water. These properties influence its formulation into tablets, injectables, and implants. The compound's stability under typical storage conditions (cool, dry, and protected from light) ensures a long shelf life. Its low solubility in water necessitates the use of carriers or solvents in pharmaceutical preparations, impacting delivery mechanisms and dosing regimens.
Main Applications
MPA is primarily used in hormonal contraception, notably in Depo-Provera injections, which provide protection for up to three months. It is also prescribed for hormone replacement therapy (HRT) in postmenopausal women and to manage endometriosis by suppressing endometrial tissue growth. In oncology, MPA treats advanced endometrial and renal cancers by inhibiting estrogen-dependent tumor growth. Off-label uses include managing abnormal uterine bleeding and supporting fertility treatments. The versatility of MPA stems from its potent progestogenic activity and customizable delivery methods.
Safety and Storage
MPA is generally safe when used as directed but may cause side effects like weight gain, mood changes, and thrombotic events. Long-term use requires monitoring for bone density loss. Proper handling in industrial settings involves using personal protective equipment to avoid inhalation or skin contact. Storage recommendations include keeping the compound in airtight containers at room temperature, away from moisture and direct sunlight. Bulk quantities should be labeled with hazard information, and disposal must comply with local regulations to prevent environmental contamination.
B2B Procurement Guide
Buyers should prioritize suppliers with certifications like GMP or ISO to ensure quality. Key procurement considerations include purity (typically 98-99.5%), packaging (e.g., aluminum foil bags for moisture protection), and regulatory documentation for intended markets. Price varies by order volume and purity; bulk purchases (e.g., 25 kg drums) often reduce costs. Due diligence is critical to avoid counterfeit products, especially for pharmaceutical-grade MPA. Establish clear terms for testing, delivery, and compliance with regional regulations (e.g., FDA or EMA approvals).
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